Peptide properties

1Top 2Function-activity relationship 3Calculated physicochemical properties 4Peptide source & Food-borne protein(s) search 5Biological/Functional activity & target protein 6Taste properties & Structure 7Preparation method 8Stability & Cytotoxicity 9Additional information 10Database cross-references 11Reference(s)

List of peptide properties

DFBP ID - DFBPNEUR0102(Neuropeptide peptide)

DFBP ID	DFBPNEUR0102
Peptide sequence	FMRF
Type	Native peptide
Peptide/Function name	Neuropeptide

Function-activity relationship

Main bioactivity	Neuropeptide activity
Otheir bioactivity	N.D

Calculated physicochemical properties

Three-letter amino acid

Phe-Met-Arg-Phe

Single-letter amino acid

FMRF

Peptide length

Peptide mass

Experimental mass	Theoretical mass
N.D	599.74 Da ^c

Net charge

0.00 ^c

Isoelectric point (pI)

11.04 ^c

IC₅₀

N.D

pIC₅₀

N.D

GRAVY

0.7500^c

Hydrophilic residue ratio

75%^c

Peptide calculator

Peptide source & Food-borne protein(s) search

Classification	Animal, Marine
Organism/Source	Clam Macrocallista nimbosa
Precursor protein	Ganglia cardioexcitatory substance
Residue position	N.D
Precursor protein(s) search	Source.1: DFBPPR3341 ---- Plant proteins ---- Transcriptional adapter ADA2 Source.2: DFBPPR4115 ---- Plant proteins ---- Cyclin-B1-2 Source.3: DFBPPR4358 ---- Plant proteins ---- Photosystem II reaction center PSB28 protein, chloroplastic Source.4: DFBPPR16933 ---- Animal proteins ---- Proenkephalin-A Source.5: DFBPPR18801 ---- Animal proteins ---- Mitochondrial pyruvate carrier 1 Source.6: DFBPPR20944 ---- Animal proteins ---- Pikachurin Source.7: DFBPPR22308 ---- Animal proteins ---- Mitochondrial pyruvate carrier-like protein Source.8: DFBPPR8794 ---- Animal proteins ---- NPC intracellular cholesterol transporter 1 Source.9: DFBPPR11707 ---- Animal proteins ---- Nuclear cap-binding protein subunit 3 Source.10: DFBPPR14473 ---- Marine protein ---- Photosystem II reaction center Psb28 protein Source.11: DFBPPR15144 ---- Microorganism protein ---- Palmitoyltransferase PFA4 Source.12: DFBPPR8120 ---- Plant protein ---- Protein TIC 214
Link-research Inductive analysis	Link 1: DFBPNEUR0095----Blue crab, Callinectes sapidus----Pericardial organs and thoracic ganglia extract protein

Biological/Functional activity & target protein

Neuropeptide activity	This neuropeptide (Phe-Met-Arg-Phe-NH₂) is active at about 10^-8 M when assayed on molluscan muscle.
Specific target protein(s)	N.D

Taste properties & Structure

Bitterness

Literature report	N.D
Bitter prediction tools	Bitter taste ^prediction

SMILES

N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)O

Preparation method

Mode of preparation	Enzymatic hydrolysis
Enzyme(s)/starter culture	Peptide structure was determined by the combined use of Edman dansyl degradation and tryptic digestion. The structure was confirmed by synthesis.

Stability & Cytotoxicity

Peptide stability

Literature report:	N.D
EHP-Tool:	Enzymatic Hydrolysis Prediction Tool (EHP-Tool)

Peptide cytotoxicity

Literature report:	N.D
Prediction:	ToxinPred

Additional information

N.D

Database cross-references

[D1]

[D2]

[D3]

[D4]

Reference(s)

Primary literature	Price DA, Greenberg MJ. Structure of a molluscan cardioexcitatory neuropeptide. Science. 1977 Aug 12;197(4304):670-1. PMID: 877582 DOI: 10.1126/science.877582
Other literature(s)	N.D
PubDate	1977