The release of vasoactive substances, 6-keto-prostaglandin F1α (stable marker of prostaglandin I2), endothelin-1, was significantly influenced by the incubation with the peptide SSS compared with control cells (P < 0.05), as shown in Table 1.
Table 1 Relative concentrations of vasoactive substances per milligram of cell protein in cell medium of human aortic endothelial cells treated with various di- and tripeptides compared to untreated cells a.
Peptides
| Concentration | Relative concentration of vasoactive substances (% of control)
| TXB2 (control = 100 ± 11)
| 6-keto-PGF1α (control = 105 ± 15)
| ET-1 (control = 100 ± 19)
| NO (control = 100 ± 29)
| H-Ser-Ser-Ser-OH
| 100 nM | 100 ± 10
| 146 ± 20*
| 113 ± 2*
| 108 ± 25 | 50 μM | 106 ± 13
| 121 ± 47
| 118 ± 2*
| 105 ± 7
| a Results are means ± SD for n=6. * Different from untreated cells; P < 0.05. | |