The release of vasoactive substances, 6-keto-prostaglandin F1α (stable marker of prostaglandin I2), was significantly influenced by the incubation with the peptide SE compared with control cells (P < 0.05), as shown in Table 1.
Table 1 Relative concentrations of vasoactive substances per milligram of cell protein in cell medium of human aortic endothelial cells treated with various di- and tripeptides compared to untreated cells a.
Peptides
| Concentration | Relative concentration of vasoactive substances (% of control)
| TXB2 (control = 100 ± 11)
| 6-keto-PGF1α (control = 105 ± 15)
| ET-1 (control = 100 ± 19)
| NO (control = 100 ± 29)
| H-Ser-Glu-OH
| 50 μM | -b
| 192 ± 47*
| 96 ± 37
| 116 ± 48 | a Results are means ± SD for n=6. b Not determined. * Different from untreated cells; P < 0.05. | |