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Enzyme - EC 3.4.21.5
DFBP ID DFBPENZY0032
EC Number EC 3.4.21.5
Term Thrombin
Introduction
DFBP ID DFBPENZY0032
EC Number EC 3.4.21.5
Accepted Name

Recommended name:
     • Thrombin
Alternative name(s):
     • Fibrinogenase

Cleavage sites
Number
Pn------
P4
P3
P2
P1
Cleavage sites
P1'
P2'
------Pm'
site.1------
-
-G
R
-|-G
-
------
site.2
------A, F, G, I, L, T, V or M
A, F, G, I, L, T, V, W or A
P
R
-|-not D or E
not D or E------
Cross-references
Database(s)
ExPASy - ENZYMEEC 3.4.21.5
MEROPS databaseN.D
ExplorEnz databaseEC 3.4.21.5
Reference(s)
Literature(s)

[1] Keil, B. Specificity of proteolysis. Springer-Verlag Berlin-Heidelberg-NewYork, pp.335. (1992)
[2] Keil, B., Tong T.N. LYSIS. Springer-Verlag Berlin-Heidelberg-NewYork, diskette set. (1992)
[2] Baughman, D.J. Thrombin assay. Methods Enzymol. 19 (1970) 145–157.
[3] Magnusson, S. Bovine prothrombin and thrombin. Methods Enzymol. 19 (1970) 157–184.
[4] Miller, K.D. Horse prothrombin. Methods Enzymol. 19 (1970) 140–145.
[5] Lundblad, R.L., Kingdon, H.S. and Mann, K.G. Thrombin. Methods Enzymol. 45 (1976) 156–176. [DOI] [PMID: 1011989]
[6] Mann, K.G. Prothrombin. Methods Enzymol. 45 (1976) 123–156. [DOI] [PMID: 1011988]
[7] Davie, E.W., Fujikawa, K., Kurachi, K. and Kisiel, W. The role of serine proteases in the blood coagulation cascade. Adv. Enzymol. 48 (1979) 277–318. [PMID: 367103]
[8] Cho, K., Tanaka, T., Cook, R.R., Kisiel, W., Fujikawa, K., Kurachi, K. and Powers, J.C. Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates. Biochemistry 23 (1984) 644–650. [PMID: 6370301]
[9] MacGillivray, R.T.A. and Davie, E.W. Characterization of bovine prothrombin mRNA and its translation product. Biochemistry 23 (1984) 1626–1634. [PMID: 6326805]

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