| Enzyme - EC 3.4.21.1 |
|
| DFBP ID |
DFBPENZY0043 |
| EC Number |
EC 3.4.21.1 |
| Term |
Chymotrypsin
|
|
| Introduction |
|
| DFBP ID |
DFBPENZY0043 |
| EC Number |
EC 3.4.21.1 |
| Accepted Name |
Accepted Name:
• Chymotrypsin
Alternative name(s):
• Alpha-chymotrypsin
• Chymotrypsin A
• Chymotrypsin B |
| Cleavage sites |
Number
| Pn------
| P4
| P3
| P2
| P1
| Cleavage sites
| P1'
| P2'
| ------Pm'
| | site.1 | ------
| -
| - | -
| Y
| -|- | - | -
| ------ | site.2
| ------ | -
| -
| -
| W
| -|- | - | -
| ------ | site.3
| ------ | -
| -
| -
| F
| -|- | -
| -
| ------ | site.4
| ------ | -
| -
| -
| L
| -|- | -
| -
| ------ | site.5
| ------ | -
| -
| -
| N
| -|- | -
| -
| ------ | site.6
| ------ | -
| -
| -
| H
| -|- | -
| -
| ------ | site.7
| ------ | -
| -
| -
| M
| -|- | -
| -
| ------ |
|
|
| Reference(s) |
|
| Literature(s) |
[1] Wilcox, P.E. Chymotrypsinogens - chymotrypsins. Methods Enzymol. 19 (1970) 64–108.
[2] Blow, D.M. Structure and mechanism of chymotrypsin. Acc. Chem. Res. 9 (1976) 145–152.
[3] Bauer, C.-A. Active centers of α-chymotrypsin and of Streptomyces griseus proteases 1 and 3. Eur. J. Biochem. 105 (1980) 565–570. [DOI] [PMID: 6768556]
[4] Polgár, L. Structure and function of serine proteases. In: Neuberger, A. and Brocklehurst, K. (Ed.), New Comprehensive Biochemistry: Hydrolytic Enzymes, vol. 16, Elsevier, Amsterdam, 1987, pp. 159–200.
[4] Tomita, N., Izumoto, Y., Horii, A., Doi, S., Yokouchi, H., Ogawa, M.,
Mori, T. and Matsubara, K. Molecular cloning and nucleotide sequence of
human pancreatic prechymotrypsinogen cDNA. Biochem. Biophys. Res. Commun. 158 (1989) 569–575. [DOI] [PMID: 2917002]
|
|
