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Enzyme - EC 3.4.21.36
DFBP ID DFBPENZY0044
EC Number EC 3.4.21.36
Term Pancreatic elastase
Introduction
DFBP ID DFBPENZY0044
EC Number EC 3.4.21.36
Accepted Name

Accepted name:
     • Pancreatic elastase
Alternative name(s):
     • Pancreatic elastase I
     • Pancreatopeptidase E

Cleavage sites
Number
Pn------
P4
P3
P2
P1
Cleavage sites
P1'
P2'
------Pm'
site.1------
-
--
A
-|---
------
site.2
-------
-
-
G
-|---
------
site.3
-------
-
-
V
-|--
-
------
site.4
-------
-
-
L
-|--
-
------
site.5
-------
-
-
I
-|--
-
------
site.6
-------
-
-
Y
-|--
-
------
site.7
-------
-
-
S
-|--
-
------
site.8
-------
-
-
T
-|--
-
------
Cross-references
Database(s)
ExPASy - ENZYMEEC 3.4.21.36
MEROPS databaseEnzyme ID S01.153
ExplorEnz database
EC 3.4.21.36
Reference(s)
Literature(s)

[1] Shotton, D.M. Elastase. Methods Enzymol. 19 (1970) 113–140.
[2] Harper, J.W., Cook, R.R., Roberts, C.J., McLaughlin, B.J. and Powers, J.C. Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II, bovine chymotrypsin Aα, and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester substrates. Biochemistry 23 (1984) 2995–3002. [PMID: 6380580]
[3] Kawashima, I., Tani, T., Shimoda, K. and Takiguchi, Y. Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas. DNA 6 (1987) 163–172. [DOI] [PMID: 3646943]
[4] Bieth, J.G., Dirrig, S., Jung, M.-L., Boudier, C., Papamichael, E., Sakarellos, C. and Dimicoli, J.-L. Investigation of the active center of rat pancreatic elastase. Biochim. Biophys. Acta 994 (1989) 64–74. [DOI] [PMID: 2909256]
[5] Bode, W., Meyer, E., Jr. and Powers, J.C. Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors. Biochemistry 28 (1989) 1951–1963. [PMID: 2655701]

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