| Enzyme - EC 3.4.21.37 |
|
| DFBP ID |
DFBPENZY0051 |
| EC Number |
EC 3.4.21.37 |
| Term |
Leukocyte elastase |
|
| Introduction |
|
| DFBP ID |
DFBPENZY0051 |
| EC Number |
EC 3.4.21.37 |
| Accepted Name |
Accepted name:
• Leukocyte elastase
Alternative name(s):
• Bone marrow serine protease
• Lysosomal elastase
• Medullasin
• Neutrophil elastase |
| Cleavage sites |
Number
| Pn------
| P4
| P3
| P2
| P1
| Cleavage sites
| P1'
| P2'
| ------Pm'
| | site.1 | ------
| -
| - | -
| V
| -|- | - | -
| ------ | site.2
| ------ | -
| -
| -
| A
| -|- | - | -
| ------ | site.3
| ------ | -
| -
| -
| S
| -|- | -
| -
| ------ | site.4
| ------ | -
| -
| -
| I
| -|- | -
| -
| ------ | site.5
| ------ | -
| -
| -
| L
| -|- | -
| -
| ------ | site.6
| ------ | -
| -
| -
| T
| -|- | -
| -
| ------ | site.7
| ------ | -
| -
| -
| N
| -|- | -
| -
| ------ |
|
|
| Reference(s) |
|
| Literature(s) |
[1] Barrett, A.J. Leukocyte elastase. Methods Enzymol. 80 (1981) 581–588. [PMID: 7043201]
[2] Harper, J.W., Cook, R.R., Roberts, C.J., McLaughlin, B.J. and Powers,
J.C. Active site mapping of the serine proteases human leukocyte
elastase, cathepsin G, porcine pancreatic elastase, rat mast cell
proteases I and II, bovine chymotrypsin Aα, and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester substrates. Biochemistry 23 (1984) 2995–3002. [PMID: 6380580]
[3] Stein, R.L., Strimpler, A.M., Hori, H. and Powers, J.C. Catalysis by
human leukocyte elastase: mechanistic insights into specificity
requirements. Biochemistry 26 (1987) 1301–1305. [PMID: 3646070]
[4] Bode, W., Meyer, E., Jr. and Powers, J.C. Human leukocyte and porcine
pancreatic elastase: X-ray crystal structures, mechanism, substrate
specificity, and mechanism-based inhibitors. Biochemistry 28 (1989) 1951–1963. [PMID: 2655701]
|
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