Enzyme

Enzyme - EC 3.4.22.53

DFBP ID	DFBPENZY0055
EC Number	EC 3.4.22.53
Term	Calpain-2

Introduction

DFBP ID

DFBPENZY0055

EC Number

EC 3.4.22.53

Accepted Name

Calcium-activated neutral protease II
M-calpain
Milli-calpain

Cleavage sites

Number	Pn------	P4	P3	P2	P1	Cleavage sites	P1'	P2'	------Pm'
site.1	------	-	-	-	K	-\|-	-	-	------
site.2	------	-	-	-	R	-\|-	-	-	------
site.3	------	-	-	-	G	-\|-	-	-	------
site.4	------	-	-	-	-	-\|-	A	-	------
site.5	------	-	-	-	-	-\|-	S	-	------
site.6	------	-	-	-	T	-\|-	-	-	------
site.7	------	-	-	-	L	-\|-	-	-	------
site.8	------	-	-	-	Q	-\|-	-	-	------

Cross-references

Database(s)

ExPASy - ENZYME	EC 3.4.22.53
MEROPS database	Enzyme ID C02.002
ExplorEnz database	EC 3.4.22.53

Reference(s)

Literature(s)

[1] Strobl, S., Fernandez-Catalan, C., Braun, M., Huber, R., Masumoto, H., Nakagawa, K., Irie, A., Sorimachi, H., Bourenkow, G., Bartunik, H., Suzuki, K. and Bode, W. The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium. Proc. Natl. Acad. Sci. USA 97 (2000) 588–592. [DOI] [PMID: 10639123]
[2] Dutt, P., Spriggs, C.N., Davies, P.L., Jia, Z. and Elce, J.S. Origins of the difference in Ca²⁺ requirement for activation of μ- and m-calpain. Biochem. J. 367 (2002) 263–269. [DOI] [PMID: 12014988]