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Enzyme - EC 3.4.21.4
DFBP ID DFBPENZY0059
EC Number EC 3.4.21.4
Term Trypsin
Introduction
DFBP ID DFBPENZY0059
EC Number EC 3.4.21.4
Accepted Name

Accepted name:
     • Trypsin
Alternative name(s):
     • Alpha-trypsin
     • Beta-trypsin

Cleavage sites
Number
Pn------
P4
P3
P2
P1
Cleavage sites
P1'
P2'
------Pm'
site.1------
-
--
K
-|--
-
------
site.2
-------
-
-
R
-|--
-
------
Cross-references
Database(s)
ExPASy - ENZYMEEC 3.4.21.4
MEROPS databaseEnzyme ID S01.151
ExplorEnz database
EC 3.4.21.4
Reference(s)
Literature(s)

[1] Huber, R. and Bode, W. Structural basis of the activation and action of trypsin. Acc. Chem. Res. 11 (1978) 114–122.
[2] Walsh, K.A. Trypsinogens and trypsins of various species. Methods Enzymol. 19 (1970) 41–63.
[3] Read, R.J., Brayer, G.D., Jurásek, L. and James, M.N.G. Critical evaluation of comparative model building of Streptomyces griseus trypsin. Biochemistry 23 (1984) 6570–6575. [PMID: 6442164]
[4] Fiedler, F. Effects of secondary interactions on the kinetics of peptide and peptide ester hydrolysis by tissue kallikrein and trypsin. Eur. J. Biochem. 163 (1987) 303–312. [DOI] [PMID: 3643848]
[5] Fletcher, T.S., Alhadeff, M., Craik, C.S. and Largman, C. Isolation and characterization of a cDNA encoding rat cationic trypsinogen. Biochemistry 26 (1987) 3081–3086. [PMID: 3112218]
[6] Polgár, L. Structure and function of serine proteases.  In: Neuberger, A. and Brocklehurst, K. (Ed.), New Comprehensive Biochemistry: Hydrolytic Enzymes, vol. 16, Elsevier, Amsterdam, 1987, pp. 159–200.
[7] Tani, T., Kawashima, I., Mita, K. and Takiguchi, Y. Nucleotide sequence of the human pancreatic trypsinogen III cDNA. Nucleic Acids Res. 18 (1990) 1631. [DOI] [PMID: 2326201]

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