Target Protein

DFBPID

TPACEI0027

ProteinName

Angiotensin-converting enzyme

Function

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.

TargetGene

Specific Target Gene
Target protein:	Recommended name: • Angiotensin-converting enzyme (EC:3.2.1.-, EC:3.4.15.1) ▪ Short name: ACE Alternative name(s): • Dipeptidyl carboxypeptidase I • CD_antigen: CD143 Cleaved into the following chain: • Angiotensin-converting enzyme, soluble form
Target gene ID:	ACE
Organism of Target:	Homo sapiens (Human)
Taxonomic identifier:	9606 [NCBI]
Target Uniprot ID:	P12821
Target ChEMBL ID:	CHEMBL1808
Target TTD ID:	T82577

Diseases

Diseases associated with this peptide
Ischemic stroke (ISCHSTR)	See also OMIM:601367
Renal tubular dysgenesis (RTD)	See also OMIM:267430
Microvascular complications of diabetes 3 (MVCD3)	See also OMIM:612624
Intracerebral hemorrhage (ICH)	See also OMIM:614519

Pathways

Enzyme and pathway databases of target protein
BRENDA	3.4.15.1 2681
Reactome	R-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins