Thrombin, which cleaves bonds after Arg and Lys,
converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII,
and, in complex with thrombomodulin, protein C. Functions in blood
homeostasis, inflammation and wound healing.
R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation R-HSA-140875 Common Pathway of Fibrin Clot Formation R-HSA-159740 Gamma-carboxylation of protein precursors R-HSA-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus R-HSA-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-375276 Peptide ligand-binding receptors R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-416476 G alpha (q) signalling events R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs) R-HSA-76009 Platelet Aggregation (Plug Formation) R-HSA-977606 Regulation of Complement cascade
