Target Protein

DFBPID

TPANTH0005

ProteinName

Coagulation factor X

Function

Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.

TargetGene

Specific Target Gene
Target protein:	Recommended name: • Coagulation factor X (EC:3.4.21.6) ▪ Short-name: FX Alternative name(s): • Stuart factor • Stuart-Prower factor • Coagulation factor Xa ▪ Short-name: FXa Cleaved into the following 3 chains: • Factor X light chain • Factor X heavy chain • Activated factor Xa heavy chain
Target gene ID:	F10
Organism of Target:	Homo sapiens (Human)
Taxonomic identifier:	9606 [NCBI]
Target Uniprot ID:	P00742
Target ChEMBL ID:	CHEMBL244
Target TTD ID:	T84631

Diseases

Diseases associated with this peptide
• Factor X deficiency (FA10D)	See also OMIM:227600

Pathways

Enzyme and pathway databases of target protein
BRENDA	3.4.21.6 2681
Reactome	R-HSA-140834 Extrinsic Pathway of Fibrin Clot Formation R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation R-HSA-140875 Common Pathway of Fibrin Clot Formation R-HSA-159740 Gamma-carboxylation of protein precursors R-HSA-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus R-HSA-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins

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