Target Protein

DFBPID

TPANTH0006

ProteinName

Coagulation factor XII

Function

Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa.

TargetGene

Specific Target Gene
Target protein:	Recommended name: • Coagulation factor XII (EC:3.4.21.38) ▪ Short-name: FXII Alternative name(s): • Hageman factor ▪ Short-name: HAF • Coagulation factor XIIa ▪ Short-name: FXIIa Cleaved into the following 3 chains: • Coagulation factor XIIa heavy chain • Beta-factor XIIa part 1 • Coagulation factor XIIa light chain Alternative name(s): ▪ Beta-factor XIIa part 2
Target gene ID:	F12
Organism of Target:	Homo sapiens (Human)
Taxonomic identifier:	9606 [NCBI]
Target Uniprot ID:	P00748
Target ChEMBL ID:	CHEMBL2821
Target TTD ID:	T10482

Diseases

Diseases associated with this peptide
• Factor XII deficiency (FA12D)	See also OMIM:234000
• Hereditary angioedema 3 (HAE3)	See also OMIM:610618

Pathways

Enzyme and pathway databases of target protein
BRENDA	3.4.21.38 2681
Reactome	R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation