Target Protein

DFBPID

TPANTH0008

ProteinName

Integrin alpha-IIb

Function

Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.

TargetGene

Specific Target Gene
Target protein:	Recommended name: • Integrin alpha-IIb Alternative name(s): • GPalpha IIb ▪ Short-name: GPIIb • Platelet membrane glycoprotein IIb • CD_antigen: CD41 Cleaved into the following 3 chains: • Integrin alpha-IIb heavy chain • Integrin alpha-IIb light chain, form 1 • Integrin alpha-IIb light chain, form 2
Target gene ID:	ITGA2B
Organism of Target:	Homo sapiens (Human)
Taxonomic identifier:	9606 [NCBI]
Target Uniprot ID:	P08514
Target ChEMBL ID:	CHEMBL212
Target TTD ID:	T50688

Diseases

Diseases associated with this peptide
• Glanzmann thrombasthenia (GT)	See also OMIM:273800
• Bleeding disorder, platelet-type 16 (BDPLT16)	See also OMIM:187800

Pathways

Enzyme and pathway databases of target protein

Reactome

R-HSA-114608 Platelet degranulation
R-HSA-216083 Integrin cell surface interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-354192 Integrin alphaIIb beta3 signaling
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins
R-HSA-445144 Signal transduction by L1
R-HSA-5674135 MAP2K and MAPK activation
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function