Target Protein

DFBPID

TPANTH0009

ProteinName

Integrin alpha-2

Function

Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.

TargetGene

Specific Target Gene
Target protein:	Recommended name: • Integrin alpha-2 Alternative name(s): • CD49 antigen-like family member B • Collagen receptor • Platelet membrane glycoprotein Ia ▪ Short-name: GPIa • VLA-2 subunit alpha • CD_antigen: CD49b
Target gene ID:	ITGA2
Organism of Target:	Homo sapiens (Human)
Taxonomic identifier:	9606 [NCBI]
Target Uniprot ID:	P17301
Target ChEMBL ID:	CHEMBL4998
Target TTD ID:	T55293

Diseases

Diseases associated with this peptide
Solid tumours [ICD9: 140-199, 210-229; ICD10: C00-D48]

Pathways

Enzyme and pathway databases of target protein
Reactome	R-HSA-216083 Integrin cell surface interactions R-HSA-3000157 Laminin interactions R-HSA-3000170 Syndecan interactions R-HSA-3000178 ECM proteoglycans R-HSA-447041 CHL1 interactions R-HSA-75892 Platelet Adhesion to exposed collagen R-HSA-8874081 MET activates PTK2 signaling