Target Protein

DFBPID

TPANTH0013

ProteinName

Coagulation factor VIII

Function

Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa.

TargetGene

Specific Target Gene
Target protein:	Recommended name: • Coagulation factor VIII ▪ Short name: FVIII Alternative name(s): • Antihemophilic factor ▪ Short name: AHF • Procoagulant component • Coagulation factor VIIIa ▪ Short name: FVIIIa Cleaved into the following 4 chains: • Factor VIIIa heavy chain, 200 kDa isoform • Factor VIIIa heavy chain, 92 kDa isoform • Factor VIII B chain • Factor VIIIa light chain
Target gene ID:	F8
Organism of Target:	Homo sapiens (Human)
Taxonomic identifier:	9606 [NCBI]
Target Uniprot ID:	P00451
Target ChEMBL ID:	CHEMBL3143
Target TTD ID:	T14602, T02690

Diseases

Diseases associated with this peptide
Hemophilia A (HEMA)	See also OMIM:306700

Pathways

Enzyme and pathway databases of target protein
Reactome	R-HSA-114608 Platelet degranulation R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation R-HSA-140875 Common Pathway of Fibrin Clot Formation R-HSA-204005 COPII-mediated vesicle transport R-HSA-5694530 Cargo concentration in the ER

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