Target Protein

DFBPID

TPANTH0023

ProteinName

Platelet glycoprotein IX

Function

The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib.

TargetGene

Specific Target Gene
Target protein:	Recommended name: • Platelet glycoprotein IX ▪ Short name: GP-IX ▪ Short name: GPIX Alternative name(s): • Glycoprotein 9 • CD_antigen: CD42a
Target gene ID:	GP9
Organism of Target:	Homo sapiens (Human)
Taxonomic identifier:	9606 [NCBI]
Target Uniprot ID:	P14770
Target ChEMBL ID:	N.D
Target TTD ID:	N.D

Diseases

Diseases associated with this peptide
Bernard-Soulier syndrome (BSS)	See also OMIM:231200

Pathways

Enzyme and pathway databases of target protein
Reactome	R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation R-HSA-430116 GP1b-IX-V activation signalling R-HSA-75892 Platelet Adhesion to exposed collagen R-HSA-76009 Platelet Aggregation (Plug Formation)