Target Protein

DFBPID

TPANTH0024

ProteinName

Platelet glycoprotein Ib alpha chain

Function

GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.

TargetGene

Specific Target Gene
Target protein:	Recommended name: • Platelet glycoprotein Ib alpha chain ▪ Short name: GP-Ib alpha ▪ Short name: GPIb-alpha ▪ Short name: GPIbA ▪ Short name: Glycoprotein Ibalpha Alternative name(s): • Antigen CD42b-alpha • CD_antigen: CD42b Cleaved into the following chain: • Glycocalicin
Target gene ID:	GP1BA
Organism of Target:	Homo sapiens (Human)
Taxonomic identifier:	9606 [NCBI]
Target Uniprot ID:	P07359
Target ChEMBL ID:	N.D
Target TTD ID:	T17427

Diseases

Diseases associated with this peptide
Non-arteritic anterior ischemic optic neuropathy (NAION)	See also OMIM:258660
Bernard-Soulier syndrome (BSS)	See also OMIM:231200
Bernard-Soulier syndrome A2, autosomal dominant (BSSA2)	See also OMIM:153670
Pseudo-von Willebrand disease (VWDP)	See also OMIM:177820

Pathways

Enzyme and pathway databases of target protein
Reactome	R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation R-HSA-430116 GP1b-IX-V activation signalling R-HSA-75892 Platelet Adhesion to exposed collagen R-HSA-76009 Platelet Aggregation (Plug Formation) R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function