Target Protein

DFBPID

TPANTH0025

ProteinName

Platelet glycoprotein Ib beta chain

Function

Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium.

TargetGene

Specific Target Gene
Target protein:	Recommended name: • Platelet glycoprotein Ib beta chain ▪ Short name: GP-Ib beta ▪ Short name: GPIb-beta ▪ Short name: GPIbB ▪ Short name: Glycoprotein Ibalpha Alternative name(s): • Antigen CD42b-beta • CD_antigen: CD42c
Target gene ID:	GP1BB
Organism of Target:	Homo sapiens (Human)
Taxonomic identifier:	9606 [NCBI]
Target Uniprot ID:	P13224
Target ChEMBL ID:	N.D
Target TTD ID:	N.D

Diseases

Diseases associated with this peptide
Bernard-Soulier syndrome (BSS)	See also OMIM:231200

Pathways

Enzyme and pathway databases of target protein
Reactome	R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation R-HSA-430116 GP1b-IX-V activation signalling R-HSA-75892 Platelet Adhesion to exposed collagen R-HSA-76009 Platelet Aggregation (Plug Formation)