Target Protein

DFBPID

TPANTH0041

ProteinName

Platelet glycoprotein 4

Function

Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects.

TargetGene

Specific Target Gene
Target protein:	Recommended name: • Platelet glycoprotein 4 Alternative name(s): • Fatty acid translocase ▪ Short name: FAT • Glycoprotein IIIb ▪ Short name: GPIIIB • Leukocyte differentiation antigen CD36 • PAS IV • PAS-4 • Platelet collagen receptor • Platelet glycoprotein IV ▪ Short name: GPIV • Thrombospondin receptor • CD_antigen: CD36
Target gene ID:	CD36 Synonyms: GP3B, GP4
Organism of Target:	Bos taurus (Bovine)
Taxonomic identifier:	9913 [NCBI]
Target Uniprot ID:	P16671
Target ChEMBL ID:	CHEMBL1744526
Target TTD ID:	T76286

Diseases

Diseases associated with this peptide
Platelet glycoprotein IV deficiency (PG4D)	See also OMIM:608404
Coronary heart disease 7 (CHDS7)	See also OMIM:610938

Pathways

Enzyme and pathway databases of target protein

Reactome

R-HSA-114608 Platelet degranulation
R-HSA-1236973 Cross-presentation of particulate exogenous antigens (phagosomes)
R-HSA-1236974 ER-Phagosome pathway
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-1989781 PPARA activates gene expression
R-HSA-3000471 Scavenging by Class B Receptors
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-5602498 MyD88 deficiency (TLR2/4)
R-HSA-5603041 IRAK4 deficiency (TLR2/4)
R-HSA-5686938 Regulation of TLR by endogenous ligand
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6798695 Neutrophil degranulation