| Function |
Cleaved by the protease thrombin to yield monomers
which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG),
polymerize to form an insoluble fibrin matrix. Fibrin has a major
function in hemostasis as one of the primary components of blood clots.
In addition, functions during the early stages of wound repair to
stabilize the lesion and guide cell migration during
re-epithelialization. Was originally thought to be essential for
platelet aggregation, based on in vitro studies using anticoagulated
blood. However subsequent studies have shown that it is not absolutely
required for thrombus formation in vivo. Enhances expression of SELP in
activated platelets. Maternal fibrinogen is essential for successful
pregnancy. Fibrin deposition is also associated with infection, where it
protects against IFNG-mediated hemorrhage. May also facilitate the
antibacterial immune response via both innate and T-cell mediated
pathways. |
