| Function |
G-protein coupled opioid receptor that functions
as receptor for endogenous alpha-neoendorphins and dynorphins, but has
low affinity for beta-endorphins. Also functions as receptor for various
synthetic opioids and for the psychoactive diterpene salvinorin A.
Ligand binding causes a conformation change that triggers signaling via
guanine nucleotide-binding proteins (G proteins) and modulates the
activity of down-stream effectors, such as adenylate cyclase. Signaling
leads to the inhibition of adenylate cyclase activity. Inhibits
neurotransmitter release by reducing calcium ion currents and increasing
potassium ion conductance. Plays a role in the perception of pain.
Plays a role in mediating reduced physical activity upon treatment with
synthetic opioids. Plays a role in the regulation of salivation in
response to synthetic opioids. May play a role in arousal and regulation
of autonomic and neuroendocrine functions. |
