Target Protein

DFBPID

TPPEPI0400

ProteinName

Prolyl endopeptidase

Function

Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.

TargetGene

Specific Target Gene
Target protein:	Recommended name: • Prolyl endopeptidase (EC:3.4.21.26) ▪ Short name: PE ▪ Short name: PEP Alternative name(s): • Post-proline cleaving enzyme
Target gene ID:	PREP
Organism of Target:	Homo sapiens (Human)
Taxonomic identifier:	9606 [NCBI]
Target Uniprot ID:	P48147
Target ChEMBL ID:	CHEMBL3202
Target TTD ID:	T86161

Diseases

Diseases associated with this peptide

Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10: F01-F07, F04, F05, R41.3]

Celiac disease [ICD9: 579; ICD10: K90.0]

Human immunodeficiency virus infection [ICD9: 279.3; ICD10: B20-B26]

Non-small cell lung cancer [ICD10: C33-C34]

Parkinson's disease [ICD9: 332; ICD10: G20]

Pathways

Enzyme and pathway databases of target protein
BRENDA	3.4.21.26 2681