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Target Protein

DFBPID TPRENI0500
ProteinName Renin
Function

Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.

TargetGene
Specific Target Gene
Target protein:
Recommended name:
     • Renin (EC:3.4.23.15)
Alternative name(s):
     • Angiotensinogenase
     • Angiotensin-forming enzyme
Target gene ID:
REN
Organism of Target:
Homo sapiens (Human)
Taxonomic identifier:
9606  [NCBI]
Target Uniprot ID:P00797
Target ChEMBL ID:
CHEMBL286
Target TTD ID:T61622
Diseases
Diseases associated with this peptide
Renal tubular dysgenesis (RTD)See also OMIM:267430
Familial juvenile hyperuricemic nephropathy 2 (HNFJ2)See also OMIM:613092
Pathways
Enzyme and pathway databases of target protein
BRENDA3.4.23.15 2681
ReactomeR-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins
SIGNORP00797
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