| Descriptors of BLOSUM62 for 20 coded amino acids. |
| AA |
Abbr. |
B1 a |
B2 |
B3 |
B4 |
B5 |
B6 |
B7 |
B8 |
B9 |
B10 |
| Ala |
A |
0.077 |
-0.916 |
0.526 |
0.004 |
0.240 |
0.190 |
0.656 |
-0.047 |
1.357 |
0.333 |
| Arg |
R |
1.014 |
0.189 |
-0.860 |
-0.609 |
1.277 |
0.195 |
0.661 |
0.175 |
-0.219 |
-0.520 |
| Asn |
N |
1.511 |
0.215 |
-0.046 |
1.009 |
0.120 |
0.834 |
-0.033 |
-0.570 |
-1.200 |
-0.139 |
| Asp |
D |
1.551 |
0.005 |
0.323 |
0.493 |
-0.991 |
0.010 |
-1.615 |
0.526 |
-0.150 |
-0.282 |
| Cys |
C |
-1.084 |
-1.112 |
1.562 |
0.814 |
1.828 |
-1.048 |
-0.742 |
0.379 |
-0.121 |
-0.102 |
| Gln |
Q |
1.094 |
0.296 |
-0.871 |
-0.718 |
0.500 |
-0.080 |
-0.442 |
0.202 |
0.384 |
0.667 |
| Glu |
E |
1.477 |
0.229 |
-0.670 |
-0.355 |
-0.284 |
-0.075 |
-1.014 |
0.363 |
0.769 |
0.298 |
| Gly |
G |
0.849 |
0.174 |
1.726 |
0.093 |
-0.548 |
1.186 |
1.213 |
0.874 |
0.009 |
0.242 |
| His |
H |
0.716 |
1.548 |
-0.802 |
1.547 |
0.350 |
-0.785 |
0.655 |
-0.076 |
-0.186 |
0.990 |
| Ile |
I |
-1.462 |
-1.126 |
-0.761 |
0.382 |
-0.599 |
0.276 |
-0.132 |
0.198 |
-0.216 |
0.207 |
| Leu |
L |
-1.406 |
-0.856 |
-0.879 |
-0.172 |
0.032 |
0.344 |
0.109 |
0.146 |
-0.436 |
-0.021 |
| Lys |
K |
1.135 |
-0.039 |
-0.802 |
-0.849 |
0.819 |
0.097 |
0.213 |
0.129 |
0.176 |
-0.850 |
| Met |
M |
-0.963 |
-0.585 |
-0.972 |
-0.528 |
0.236 |
0.365 |
0.062 |
0.208 |
-0.560 |
0.361 |
| Phe |
F |
-1.619 |
1.007 |
-0.311 |
0.623 |
-0.549 |
0.290 |
-0.021 |
0.098 |
0.433 |
-1.288 |
| Pro |
P |
0.883 |
-0.675 |
0.382 |
-0.869 |
-1.243 |
-2.023 |
0.845 |
-0.352 |
-0.421 |
-0.298 |
| Ser |
S |
0.844 |
-0.448 |
0.423 |
0.317 |
0.200 |
0.541 |
0.009 |
-0.797 |
0.624 |
-0.129 |
| Thr |
T |
0.188 |
-0.733 |
0.178 |
-0.012 |
0.022 |
0.378 |
-0.304 |
-1.958 |
0.149 |
0.063 |
| Trp |
W |
-1.577 |
2.281 |
1.166 |
-1.610 |
0.122 |
0.239 |
-0.542 |
-0.398 |
-0.349 |
0.499 |
| Tyr |
Y |
-1.142 |
1.740 |
-0.582 |
0.747 |
-0.119 |
-0.475 |
0.241 |
-0.251 |
0.713 |
-0.251 |
| Val |
V |
-1.127 |
-1.227 |
-0.633 |
0.064 |
-0.596 |
0.158 |
0.014 |
0.016 |
0.251 |
0.607 |
| a The BLOSUM matrix-derived descriptors (BLOSUM) including 10 indices, representing hydrophobicity, alpha-helix propensity, beta-sheet propensity, bulkiness, charge, and composition, are based on both physicochemical properties that have been subjected to a ARIMAX analyses and an alignment matrix of 20 coded amino acids, the BLOSUM62 matrix. |
| References |
[1] A. G. Georgiev, Interpretable numerical descriptors of amino acid space, J. Comput. Biol., 16 (2009) 703-723.
[2] S. Henikoff, J. G. Henikoff, Amino acid substitution matrices from protein blocks, Proc. Natl. Acad. Sci. U. S. A., 89 (1992) 10915-10919. |
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