| Descriptors of FASGAI for 20 coded amino acids. |
| AA |
Abbr. |
Factor1 a |
Factor2 |
Factor3 |
Factor4 |
Factor5 |
Factor6 |
| Ala |
A |
0.207 |
0.821 |
-1.009 |
1.387 |
0.063 |
-0.600 |
| Arg |
R |
-1.229 |
0.378 |
0.516 |
-0.328 |
-0.052 |
2.728 |
| Asn |
N |
-1.009 |
-0.939 |
-0.428 |
-0.397 |
-0.539 |
-0.605 |
| Asp |
D |
-1.298 |
-0.444 |
-0.584 |
-0.175 |
-0.259 |
-1.762 |
| Cys |
C |
0.997 |
0.021 |
-1.419 |
-2.080 |
-0.799 |
0.502 |
| Gln |
Q |
-0.880 |
0.381 |
-0.044 |
-0.455 |
-0.040 |
0.405 |
| Glu |
E |
-1.349 |
1.388 |
-0.361 |
0.213 |
0.424 |
-1.303 |
| Gly |
G |
-0.205 |
-2.219 |
-1.656 |
1.229 |
-1.115 |
-1.146 |
| His |
H |
-0.270 |
0.461 |
-0.024 |
-1.407 |
0.001 |
0.169 |
| Ile |
I |
1.524 |
0.536 |
0.809 |
0.734 |
-0.196 |
0.427 |
| Leu |
L |
1.200 |
1.128 |
0.703 |
1.904 |
0.536 |
-0.141 |
| Lys |
K |
-1.387 |
0.572 |
0.285 |
0.333 |
-0.169 |
1.157 |
| Met |
M |
0.886 |
1.346 |
0.277 |
-0.913 |
0.007 |
-0.265 |
| Phe |
F |
1.247 |
0.293 |
1.336 |
-0.026 |
0.012 |
-0.015 |
| Pro |
P |
-0.407 |
-2.038 |
-0.564 |
-0.128 |
3.847 |
-1.008 |
| Ser |
S |
-0.495 |
-0.847 |
-1.079 |
0.582 |
0.035 |
-0.068 |
| Thr |
T |
-0.032 |
-0.450 |
-0.610 |
0.341 |
0.117 |
0.577 |
| Trp |
W |
0.844 |
-0.075 |
2.069 |
-1.360 |
-0.810 |
-0.380 |
| Tyr |
Y |
0.329 |
-0.858 |
1.753 |
-0.479 |
-0.835 |
0.289 |
| Val |
V |
1.332 |
0.545 |
0.029 |
1.026 |
-0.229 |
1.038 |
| a Through factor analysis, the FASGAI descriptors cluster 334 physicochemical properties of each of 20 coded amino acids into 6 factors, which are related to hydrophobicity, alpha and turn propensities, bulky properties, compositional characteristics, local flexibility and electronic properties, respectively. |
| References |
[1] G. Z. Liang, G. H. Chen, W. H. Niu, Z. L. Li, Factor analysis scales of generalized amino acid information as applied in predicting interactions between the human amphiphysin-1 SH3 domains and their peptide ligands, Chem. Biol. Drug Des., 71 (2008) 345-351. |
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