| Descriptors of NNAAIndex for 20 coded amino acids. |
| AA |
Abbr. |
Factor1 a |
Factor2 |
Factor3 |
Factor4 |
Factor5 |
Factor6 |
| Ala |
A |
-1.319 |
-0.418 |
-0.571 |
0.490 |
-0.165 |
-2.024 |
| Arg |
R |
-0.245 |
0.161 |
-1.192 |
0.117 |
1.278 |
0.349 |
| Asn |
N |
-0.913 |
1.796 |
-0.880 |
0.061 |
-0.775 |
-0.858 |
| Asp |
D |
-1.183 |
0.705 |
-0.603 |
0.222 |
-0.748 |
-1.376 |
| Cys |
C |
-1.068 |
0.023 |
-0.808 |
0.537 |
-0.113 |
-1.055 |
| Gln |
Q |
-0.721 |
1.887 |
-0.887 |
-0.030 |
-0.251 |
-0.281 |
| Glu |
E |
-0.726 |
1.814 |
-0.870 |
0.095 |
-0.671 |
-0.005 |
| Gly |
G |
-1.515 |
-0.272 |
-0.009 |
0.606 |
-0.496 |
-1.792 |
| His |
H |
-0.654 |
1.027 |
0.967 |
-0.020 |
0.166 |
-0.304 |
| Ile |
I |
-0.705 |
-0.380 |
-1.537 |
0.055 |
0.516 |
-1.071 |
| Leu |
L |
-0.694 |
-0.336 |
-1.357 |
0.061 |
0.774 |
-0.807 |
| Lys |
K |
-0.523 |
0.063 |
-0.949 |
-0.104 |
0.427 |
0.302 |
| Met |
M |
-0.657 |
-0.310 |
-0.988 |
0.074 |
1.316 |
0.321 |
| Phe |
F |
-0.427 |
-0.150 |
0.783 |
-0.304 |
1.049 |
0.130 |
| Pro |
P |
-1.004 |
-1.165 |
0.941 |
0.285 |
1.026 |
-1.492 |
| Ser |
S |
-1.210 |
1.428 |
-0.631 |
0.342 |
-1.030 |
-1.424 |
| Thr |
T |
-1.024 |
1.143 |
-1.107 |
0.201 |
-0.636 |
-1.408 |
| Trp |
W |
0.072 |
-0.027 |
1.454 |
-0.444 |
0.767 |
0.071 |
| Tyr |
Y |
-0.202 |
-0.061 |
0.638 |
-0.236 |
-0.101 |
0.459 |
| Val |
V |
-0.924 |
-0.464 |
-1.305 |
0.165 |
0.450 |
-1.416 |
| a The NNAAIndex scales characterize a total of 155 physiochemical properties of 22 natural and 593 non-natural amino acids, followed by clustering the structural matrix into 6 representative property patterns by factor analysis. The six factors are geometric characteristics, H-bond, connectivity, accessible surface area, integy moments index, and volume and shape, respectively. |
| References |
[1] G. Liang, Y. Liu, B. Shi, J. Zhao, J. Zheng, An index for characterization of natural and non-natural amino acids for peptidomimetics, PLoS One, 8 (2013) e67844. |
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