Descriptors of VHSE for 20 coded amino acids.
AA	Abbr.	VHSE1a	VHSE2	VHSE3	VHSE4	VHSE5	VHSE6	VHSE7	VHSE8
Ala	A	0.15	-1.11	-1.35	-0.92	0.02	-0.91	0.36	-0.48
Arg	R	-1.47	1.45	1.24	1.27	1.55	1.47	1.30	0.83
Asn	N	-0.99	0.00	-0.37	0.69	-0.55	0.85	0.73	-0.80
Asp	D	-1.15	0.67	-0.41	-0.01	-2.68	1.31	0.03	0.56
Cys	C	0.18	-1.67	-0.46	-0.21	0.00	1.20	-1.61	-0.19
Gln	Q	-0.96	0.12	0.18	0.16	0.09	0.42	-0.20	-0.41
Glu	E	-1.18	0.40	0.10	0.36	-2.16	-0.17	0.91	0.02
Gly	G	-0.20	-1.53	-2.63	2.28	-0.53	-1.18	2.01	-1.34
His	H	-0.43	-0.25	0.37	0.19	0.51	1.28	0.93	0.65
Ile	I	1.27	-0.14	0.30	-1.80	0.30	-1.61	-0.16	-0.13
Leu	L	1.36	0.07	0.26	-0.80	0.22	-1.37	0.08	-0.62
Lys	K	-1.17	0.70	0.70	0.80	1.64	0.67	1.63	0.13
Met	M	1.01	-0.53	0.43	0.00	0.23	0.10	-0.86	-0.68
Phe	F	1.52	0.61	0.96	-0.16	0.25	0.28	-1.33	-0.20
Pro	P	0.22	-0.17	-0.50	0.05	-0.01	-1.34	-0.19	3.56
Ser	S	-0.67	-0.86	-1.07	-0.41	-0.32	0.27	-0.64	0.11
Thr	T	-0.34	-0.51	-0.55	-1.06	-0.06	-0.01	-0.79	0.39
Trp	W	1.50	2.06	1.79	0.75	0.75	-0.13	-1.01	-0.85
Tyr	Y	0.61	1.60	1.17	0.73	0.53	0.25	-0.96	-0.52
Val	V	0.76	-0.92	-0.17	-1.91	0.22	-1.40	-0.24	-0.03
a The VHSE descriptors are derived from the PCA on independent families of 18 hydrophobic properties, 17 steric properties, and 15 electronic properties, respectively. Among them, VHSE1 and VHSE2 are related to hydrophobic properties, VHSE3 and VHSE4 to steric properties, and VHSE5–VHSE8 to electronic properties.
References [1] H. Mei, Z. H. Liao, Y. Zhou, S. Z. Li, A new set of amino acid descriptors and its application in peptide QSARs, Biopolymers, 80 (2005) 775-786.