| Descriptors of Z-scales for 20 coded amino acids. |
| AA |
Abbr. |
Z1 a |
Z2 |
Z3 |
| Ala |
A |
0.07 |
-1.73 |
0.09 |
| Arg |
R |
2.88 |
2.52 |
-3.44 |
| Asn |
N |
3.22 |
1.45 |
0.84 |
| Asp |
D |
3.64 |
1.13 |
2.36 |
| Cys |
C |
0.71 |
-0.97 |
4.13 |
| Gln |
Q |
2.18 |
0.53 |
-1.14 |
| Glu |
E |
3.08 |
0.39 |
-0.07 |
| Gly |
G |
2.23 |
-5.36 |
0.30 |
| His |
H |
2.41 |
1.74 |
1.11 |
| Ile |
I |
-4.44 |
-1.68 |
-1.03 |
| Leu |
L |
-4.19 |
-1.03 |
-0.98 |
| Lys |
K |
2.84 |
1.41 |
-3.14 |
| Met |
M |
-2.49 |
-0.27 |
-0.41 |
| Phe |
F |
-4.92 |
1.30 |
0.45 |
| Pro |
P |
-1.22 |
0.88 |
2.23 |
| Ser |
S |
1.96 |
-1.63 |
0.57 |
| Thr |
T |
0.92 |
-2.09 |
-1.40 |
| Trp |
W |
-4.75 |
3.65 |
0.85 |
| Tyr |
Y |
-1.39 |
2.32 |
0.01 |
| Val |
V |
-2.69 |
-2.53 |
-1.29 |
| a The 3 principal component scores are derived from PCA of a matrix of 29 physicochemical variables for 20 coded amino acid are related to hydrophilicity (z1), bulk (z2), and electronic properties (z3). |
| References |
[1] S. Hellberg, M. Sjostrom, B. Skagerberg, S. Wold, Peptide Quantitative structure-activity-relationships, a multivariate approach, J. Med. Chem., 30 (1987) 1126-1135. |
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