Antioxidative peptide predictor (AnOxPP) is an efficient tool to predict the antioxidative activity of peptides by using the BiLSTM neural network and the optimized amino acid descriptors SDPZ27. The non-redundant code SDPZ27 shows efficient conversion of sequence features, and interprets the importance of four decisive features of AnOxPs: Steric properties > Hydrophobic properties > Electronic properties > Hydrogen bond contributions. By learning the key sequence/structure features of AnOxPs converted by SDPZ27, AnOxPP exhibits more accurate prediction than the existing model. AnOxPP will contribute to understanding the structure−activity relationship of AnOxPs and provide a methodological reference for the application of deep learning to study bioactive peptides. You can get the following purposes through AnOxPP: (i) Predict unknown peptides in a single or batch manner; (ii) View the sequence characteristics of AnOxPs including length, mass, terminals and amino acid composition; (iii) Screen the predicted AnOxPs (pre-AnOxPs) from the 'Pre-Libraries', which is constructed by using different enzymes to simulate the hydrolysis of 21249 proteins in 60 species; (iv) Download datasets of AnOxPs, non-AnOxPs and pre-AnOxPs. |
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Please cite:Qin D, Jiao L, Wang R et al. Prediction of antioxidant peptides using a quantitative structure−activity relationship predictor (AnOxPP) based on bidirectional long short-term memory neural network and interpretable amino acid descriptors, Comput. Biol. Med. 154 (2023) 106591, https://doi.org/10.1016/j.compbiomed.2023.106591. Download PDF
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