DFBP ID - DFBPACEI1297(ACE-inhibitory peptide) |
DFBP ID |
DFBPACEI1297 |
Peptide sequence |
LQL |
Type |
Native peptide |
Peptide/Function name |
ACE-inhibitory peptide |
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Function-activity relationship |
Main bioactivity |
ACE-inhibitory activity |
Otheir bioactivity |
Antioxidative activity [D1], Multifunctional activity [D2] |
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Calculated physicochemical properties |
Three-letter amino acid |
Leu-Gln-Leu |
Single-letter amino acid |
LQL |
Peptide length |
3 |
Peptide mass |
Experimental mass |
Theoretical mass |
372.2 Da |
372.46 Da c |
|
Net charge |
0.00 c |
Isoelectric point (pI) |
5.97 c |
IC50 |
N.D |
pIC50 |
N.D |
GRAVY |
1.3667 c |
Hydrophilic residue ratio |
66.67% c |
Peptide calculator |
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Biological/Functional activity & target protein |
ACE-inhibitory activity |
The peptide exhibited 70% Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) inhibition. |
Specific target protein(s) |
Specific Target Protein(s): Angiotensin-converting enzyme |
|
Taste properties & Structure |
Bitterness |
Literature report |
N.D |
Bitter prediction tools |
Bitter taste prediction |
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SMILES |
N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)O |
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Preparation method |
Mode of preparation |
Enzymatic hydrolysis |
Enzyme(s)/starter culture |
Hemp seed proteins was hydrolyzed by simulating gastrointestinal tract digestion (Pepsin and Pancreatin). |
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Stability & Cytotoxicity |
Peptide stability |
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Peptide cytotoxicity |
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Additional information |
Additional information |
The peptide showed 65% renin inhibition.
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Database cross-references |
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Reference(s) |
Primary literature |
Girgih, A.T., He, R., Malomo, S., Offengenden, M., Wu, J., Aluko, R.E. Structural and functional characterization of hemp seed (Cannabis sativa L.) protein-derived antioxidant and antihypertensive peptides. Journal of Functional Foods. 2014, 6, 384-94.
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Other literature(s) |
N.D |
PubDate |
2014 |
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