DFBP ID - DFBPACEI1307(ACE-inhibitory peptide) |
DFBP ID |
DFBPACEI1307 |
Peptide sequence |
WAF |
Type |
Native peptide |
Peptide/Function name |
ACE-inhibitory peptide |
|
Function-activity relationship |
Main bioactivity |
ACE-inhibitory activity |
Otheir bioactivity |
Antioxidative activity [D1], Multifunctional activity [D2] |
|
Calculated physicochemical properties |
Three-letter amino acid |
Trp-Ala-Phe |
Single-letter amino acid |
WAF |
Peptide length |
3 |
Peptide mass |
Experimental mass |
Theoretical mass |
422.48 Da |
422.48 Da c |
|
Net charge |
0
|
Isoelectric point (pI) |
6.01 |
IC50 |
170 ± 5.78 uM |
pIC50 |
-2.23 |
GRAVY |
1.2333 c |
Hydrophilic residue ratio |
100% c |
Peptide calculator |
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Biological/Functional activity & target protein |
ACE-inhibitory activity |
The peptide exhibited moderate Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) inhibitory activity with an IC50
value of 170 ± 5.78 uM. |
Specific target protein(s) |
Specific Target Protein(s): Angiotensin-converting enzyme |
|
Taste properties & Structure |
Bitterness |
Literature report |
N.D |
Bitter prediction tools |
Bitter taste prediction |
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SMILES |
N[C@@]([H])(CC(=CN2)C1=C2C=CC=C1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)O |
|
Preparation method |
Mode of preparation |
Enzymatic hydrolysis |
Enzyme(s)/starter culture |
Palm kernel cake proteins was hydrolyzed with Papain. |
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Stability & Cytotoxicity |
Peptide stability |
|
Peptide cytotoxicity |
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Additional information |
Additional information |
The peptide has the potential as ingredients in functional foods and nutraceuticals. |
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Database cross-references |
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Reference(s) |
Primary literature |
Zarei, M., Forghani, B., Ebrahimpour, A., Abdul-Hamid, A., Anwar, F., Saari, N. In vitro and in vivo antihypertensive activity of palm kernel cake protein hydrolysates: Sequencing and characterization of potent bioactive peptides. Industrial Crops and Products. 2015, 76, 112-20.
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Other literature(s) |
N.D |
PubDate |
2015 |
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