Peptide properties

1Top 2Function-activity relationship 3Calculated physicochemical properties 4Peptide source & Food-borne protein(s) search 5Biological/Functional activity & target protein 6Taste properties & Structure 7Preparation method 8Stability & Cytotoxicity 9Additional information 10Database cross-references 11Reference(s)

List of peptide properties

DFBP ID - DFBPACEI1993(ACE-inhibitory peptide)

DFBP ID	DFBPACEI1993
Peptide sequence	MCS
Type	Native peptide
Peptide/Function name	ACE-inhibitory peptide

Function-activity relationship

Main bioactivity	ACE-inhibitory activity
Otheir bioactivity	N.D

Calculated physicochemical properties

Three-letter amino acid

Met-Cys-Ser

Single-letter amino acid

MCS

Peptide length

Peptide mass

Experimental mass	Theoretical mass
340.39 Da	339.43 Da ^c

Net charge

0.00 ^c

Isoelectric point (pI)

5.33 ^c

IC₅₀

0.29 μM

pIC₅₀

0.538

GRAVY

1.2000^c

Hydrophilic residue ratio

33.33%^c

Peptide calculator

Peptide source & Food-borne protein(s) search

Classification	Animal, Fish
Organism/Source	Tilapia (Oreochromis niloticus)
Precursor protein	Tilapia muscle proteins
Residue position	N.D
Precursor protein(s) search	Source.1: DFBPPR0827 ---- Plant proteins ---- Homeobox-leucine zipper protein ROC9 Source.2: DFBPPR0931 ---- Plant proteins ---- Ornithine aminotransferase, mitochondrial Source.3: DFBPPR0937 ---- Plant proteins ---- Glutamate synthase 1 [NADH], chloroplastic Source.4: DFBPPR0948 ---- Plant proteins ---- Carotenoid cleavage dioxygenase 8 homolog B, chloroplastic Source.5: DFBPPR1104 ---- Plant proteins ---- 12-oxophytodienoate reductase 7 Source.6: DFBPPR1289 ---- Plant proteins ---- bZIP transcription factor 39 Source.7: DFBPPR1458 ---- Plant proteins ---- Endoglucanase 9 Source.8: DFBPPR1499 ---- Plant proteins ---- Protein kinase and PP2C-like domain-containing protein Source.9: DFBPPR1565 ---- Plant proteins ---- Nuclear cap-binding protein subunit 1 Source.10: DFBPPR1637 ---- Plant proteins ---- Ent-copalyl diphosphate synthase 2 Source.11: DFBPPR1764 ---- Plant proteins ---- B3 domain-containing protein VP1 Source.12: DFBPPR1811 ---- Plant proteins ---- Sulfhydryl oxidase 1 Source.13: DFBPPR1830 ---- Plant proteins ---- Endoribonuclease Dicer homolog 3a Source.14: DFBPPR1880 ---- Plant proteins ---- Putative laccase-11 Source.15: DFBPPR1955 ---- Plant proteins ---- Endoribonuclease Dicer homolog 3b Source.16: DFBPPR2785 ---- Plant proteins ---- Aspartic proteinase Source.17: DFBPPR2789 ---- Plant proteins ---- NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic Source.18: DFBPPR3065 ---- Plant proteins ---- Transcription factor TGAL5 Source.19: DFBPPR3101 ---- Plant proteins ---- Putative potassium transporter 12 Source.20: DFBPPR3186 ---- Plant proteins ---- Endoglucanase 10 Source.21: DFBPPR3236 ---- Plant proteins ---- Probable adenylate kinase 6, chloroplastic Source.22: DFBPPR3249 ---- Plant proteins ---- Coatomer subunit beta'-1 Source.23: DFBPPR3388 ---- Plant proteins ---- Beta-galactosidase 14 Source.24: DFBPPR3398 ---- Plant proteins ---- Serine/threonine-protein phosphatase PP1 Source.25: DFBPPR3428 ---- Plant proteins ---- Carotenoid cleavage dioxygenase 8 homolog A, chloroplastic Source.26: DFBPPR3597 ---- Plant proteins ---- Probable potassium transporter 11 Source.27: DFBPPR3616 ---- Plant proteins ---- Probable esterase PIR7A Source.28: DFBPPR3676 ---- Plant proteins ---- Endoglucanase 6 Source.29: DFBPPR3768 ---- Plant proteins ---- Kinesin-like protein KIN-12F Source.30: DFBPPR3865 ---- Plant proteins ---- CDK5RAP1-like protein Source.31: DFBPPR3872 ---- Plant proteins ---- Endoglucanase 19 Source.32: DFBPPR3894 ---- Plant proteins ---- Cyclin-A3-1 Source.33: DFBPPR3909 ---- Plant proteins ---- LIM domain-containing protein PLIM2b Source.34: DFBPPR4016 ---- Plant proteins ---- Probable anion transporter 2, chloroplastic Source.35: DFBPPR4520 ---- Plant proteins ---- Zinc finger CCCH domain-containing protein 33 Source.36: DFBPPR4618 ---- Plant proteins ---- Zinc finger A20 and AN1 domain-containing stress-associated protein 3 Source.37: DFBPPR4626 ---- Plant proteins ---- Zinc finger A20 and AN1 domain-containing stress-associated protein 6 Source.38: DFBPPR4629 ---- Plant proteins ---- Zinc finger A20 and AN1 domain-containing stress-associated protein 7 Source.39: DFBPPR4634 ---- Plant proteins ---- Zinc finger A20 and AN1 domain-containing stress-associated protein 9 Source.40: DFBPPR4667 ---- Plant proteins ---- Zinc finger A20 and AN1 domain-containing stress-associated protein 4 Source.41: DFBPPR4669 ---- Plant proteins ---- Zinc finger A20 and AN1 domain-containing stress-associated protein 8 Source.42: DFBPPR4728 ---- Plant proteins ---- Zinc finger A20 and AN1 domain-containing stress-associated protein 12 Source.43: DFBPPR4804 ---- Plant proteins ---- Putative B3 domain-containing protein Os10g0537100 Source.44: DFBPPR4851 ---- Plant proteins ---- B3 domain-containing protein Os03g0619800 Source.45: DFBPPR4934 ---- Plant proteins ---- U-box domain-containing protein 70 Source.46: DFBPPR4937 ---- Plant proteins ---- Glutamate synthase 2 [NADH], chloroplastic Source.47: DFBPPR5107 ---- Plant proteins ---- Cytochrome c oxidase subunit 2, mitochondrial Source.48: DFBPPR5174 ---- Plant proteins ---- NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic Source.49: DFBPPR5323 ---- Plant proteins ---- Cytochrome P450 78A3 Source.50: DFBPPR5705 ---- Plant proteins ---- Tubulin beta-4 chain Source.51: DFBPPR5754 ---- Plant proteins ---- Phosphoglucomutase, cytoplasmic 1 Source.52: DFBPPR5789 ---- Plant proteins ---- Phosphoglucomutase, cytoplasmic 2 Source.53: DFBPPR5814 ---- Plant proteins ---- NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic Source.54: DFBPPR5966 ---- Plant proteins ---- Serine/threonine-protein phosphatase PP1 Source.55: DFBPPR6072 ---- Plant proteins ---- CASP-like protein 5A2 Source.56: DFBPPR6098 ---- Plant proteins ---- CASP-like protein 5A1 Source.57: DFBPPR6099 ---- Plant proteins ---- CASP-like protein 16 Source.58: DFBPPR6417 ---- Plant proteins ---- Beta-fructofuranosidase, cell wall isozyme Source.59: DFBPPR6689 ---- Plant proteins ---- Fructan 1-exohydrolase w1 Source.60: DFBPPR6715 ---- Plant proteins ---- Fructan 1-exohydrolase w3 Source.61: DFBPPR6720 ---- Plant proteins ---- Fructan 1-exohydrolase w2 Source.62: DFBPPR6831 ---- Plant proteins ---- NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic Source.63: DFBPPR6858 ---- Plant proteins ---- Glutenin, low molecular weight subunit 1D1 Source.64: DFBPPR6890 ---- Plant proteins ---- Glutenin, low molecular weight subunit PTDUCD1 Source.65: DFBPPR6947 ---- Plant proteins ---- Avenin-like b5 Source.66: DFBPPR6961 ---- Plant proteins ---- Avenin-like a2 Source.67: DFBPPR6964 ---- Plant proteins ---- Avenin-like a3 Source.68: DFBPPR6966 ---- Plant proteins ---- Avenin-like b6 Source.69: DFBPPR6969 ---- Plant proteins ---- Avenin-like b7 Source.70: DFBPPR6971 ---- Plant proteins ---- Avenin-like a7 Source.71: DFBPPR6972 ---- Plant proteins ---- Gamma-gliadin B-I Source.72: DFBPPR6973 ---- Plant proteins ---- Avenin-like a6 Source.73: DFBPPR6975 ---- Plant proteins ---- Gamma-gliadin Source.74: DFBPPR6985 ---- Plant proteins ---- Avenin-like b4 Source.75: DFBPPR6987 ---- Plant proteins ---- Ninja-family protein 1 Source.76: DFBPPR6989 ---- Plant proteins ---- Avenin-like b9 Source.77: DFBPPR6990 ---- Plant proteins ---- Avenin-like b8 Source.78: DFBPPR6991 ---- Plant proteins ---- Ninja-family protein 3 Source.79: DFBPPR7015 ---- Plant proteins ---- Phytepsin Source.80: DFBPPR7187 ---- Plant proteins ---- NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic Source.81: DFBPPR7230 ---- Plant proteins ---- Fructan 1-exohydrolase Source.82: DFBPPR7311 ---- Plant proteins ---- B1-hordein Source.83: DFBPPR7318 ---- Plant proteins ---- B3-hordein Source.84: DFBPPR7396 ---- Plant proteins ---- MAP3K epsilon protein kinase 1 Source.85: DFBPPR7404 ---- Plant proteins ---- O-fucosyltransferase 20 Source.86: DFBPPR7635 ---- Milk proteins ---- Prosaposin Source.87: DFBPPR7667 ---- Milk proteins ---- Lysozyme C, milk isozyme Source.88: DFBPPR8430 ---- Plant proteins ---- NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic Source.89: DFBPPR15937 ---- Animal proteins ---- Appetite-regulating hormone Source.90: DFBPPR16122 ---- Animal proteins ---- Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Source.91: DFBPPR16151 ---- Animal proteins ---- Serine/threonine-protein phosphatase PP1-beta catalytic subunit Source.92: DFBPPR16177 ---- Animal proteins ---- Adhesion G protein-coupled receptor E2 Source.93: DFBPPR16198 ---- Animal proteins ---- Serine/threonine-protein phosphatase PP1-alpha catalytic subunit Source.94: DFBPPR16211 ---- Animal proteins ---- Lysine-specific demethylase 5C Source.95: DFBPPR16222 ---- Animal proteins ---- Sodium- and chloride-dependent taurine transporter Source.96: DFBPPR16321 ---- Animal proteins ---- Aggrecan core protein Source.97: DFBPPR16339 ---- Animal proteins ---- Dynamin-binding protein Source.98: DFBPPR16461 ---- Animal proteins ---- InaD-like protein Source.99: DFBPPR16469 ---- Animal proteins ---- Lysozyme C, milk isozyme Source.100: DFBPPR16581 ---- Animal proteins ---- NADH-ubiquinone oxidoreductase chain 5 Source.101: DFBPPR16607 ---- Animal proteins ---- Taste receptor type 1 member 2 Source.102: DFBPPR16647 ---- Animal proteins ---- Tudor domain-containing protein 7 Source.103: DFBPPR16698 ---- Animal proteins ---- Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Source.104: DFBPPR16973 ---- Animal proteins ---- Fatty acid synthase Source.105: DFBPPR16987 ---- Animal proteins ---- Aggrecan core protein Source.106: DFBPPR17027 ---- Animal proteins ---- D(1A) dopamine receptor Source.107: DFBPPR17064 ---- Animal proteins ---- Unconventional myosin-Ic Source.108: DFBPPR17167 ---- Animal proteins ---- Calcineurin subunit B type 1 Source.109: DFBPPR17237 ---- Animal proteins ---- Pituitary adenylate cyclase-activating polypeptide Source.110: DFBPPR17336 ---- Animal proteins ---- Serine/threonine-protein phosphatase PP1-beta catalytic subunit Source.111: DFBPPR17477 ---- Animal proteins ---- Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Source.112: DFBPPR17504 ---- Animal proteins ---- Duodenase-1 Source.113: DFBPPR17510 ---- Animal proteins ---- Uroplakin-1b Source.114: DFBPPR17576 ---- Animal proteins ---- Fibrillin-1 Source.115: DFBPPR17579 ---- Animal proteins ---- Serine/threonine-protein phosphatase PP1-alpha catalytic subunit Source.116: DFBPPR17902 ---- Animal proteins ---- PDZ and LIM domain protein 4 Source.117: DFBPPR18027 ---- Animal proteins ---- NADH-ubiquinone oxidoreductase chain 5 Source.118: DFBPPR18055 ---- Animal proteins ---- E3 ubiquitin-protein ligase MARCHF8 Source.119: DFBPPR18077 ---- Animal proteins ---- Gastric triacylglycerol lipase Source.120: DFBPPR18119 ---- Animal proteins ---- Synaptic vesicular amine transporter Source.121: DFBPPR18120 ---- Animal proteins ---- Synaptic vesicular amine transporter Source.122: DFBPPR18274 ---- Animal proteins ---- Histone deacetylase 8 Source.123: DFBPPR18368 ---- Animal proteins ---- E3 ubiquitin-protein ligase TRIP12 Source.124: DFBPPR18424 ---- Animal proteins ---- Inositol 1,4,5-trisphosphate receptor type 2 Source.125: DFBPPR18467 ---- Animal proteins ---- Alpha-aminoadipic semialdehyde synthase, mitochondrial Source.126: DFBPPR18473 ---- Animal proteins ---- Sharpin Source.127: DFBPPR18809 ---- Animal proteins ---- Adenylate kinase isoenzyme 5 Source.128: DFBPPR18841 ---- Animal proteins ---- PHD finger protein 6 Source.129: DFBPPR18871 ---- Animal proteins ---- Methionine synthase Source.130: DFBPPR18935 ---- Animal proteins ---- Beta-citrylglutamate synthase B Source.131: DFBPPR18989 ---- Animal proteins ---- Secreted frizzled-related protein 5 Source.132: DFBPPR19077 ---- Animal proteins ---- Cytoplasmic dynein 1 intermediate chain 1 Source.133: DFBPPR19112 ---- Animal proteins ---- Ubiquitin-like-conjugating enzyme ATG3 Source.134: DFBPPR19195 ---- Animal proteins ---- V-type proton ATPase 116 kDa subunit a2 Source.135: DFBPPR19301 ---- Animal proteins ---- E3 ubiquitin-protein ligase RNF220 Source.136: DFBPPR19317 ---- Animal proteins ---- AP-1 complex subunit sigma-1A Source.137: DFBPPR19323 ---- Animal proteins ---- WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 Source.138: DFBPPR19402 ---- Animal proteins ---- GTP-binding protein SAR1b Source.139: DFBPPR19447 ---- Animal proteins ---- Cytochrome b561 domain-containing protein 2 Source.140: DFBPPR19454 ---- Animal proteins ---- Acetylserotonin O-methyltransferase Source.141: DFBPPR19689 ---- Animal proteins ---- Ecto-ADP-ribosyltransferase 5 Source.142: DFBPPR19832 ---- Animal proteins ---- Zinc finger CCCH domain-containing protein 14 Source.143: DFBPPR19851 ---- Animal proteins ---- GTP-binding protein SAR1a Source.144: DFBPPR19861 ---- Animal proteins ---- Phospholipid phosphatase-related protein type 2 Source.145: DFBPPR19942 ---- Animal proteins ---- AP-1 complex subunit sigma-2 Source.146: DFBPPR19963 ---- Animal proteins ---- DnaJ homolog subfamily C member 14 Source.147: DFBPPR19977 ---- Animal proteins ---- Probable ATP-dependent RNA helicase DDX27 Source.148: DFBPPR20014 ---- Animal proteins ---- Transcription factor COE2 Source.149: DFBPPR20181 ---- Animal proteins ---- Choline transporter-like protein 2 Source.150: DFBPPR20349 ---- Animal proteins ---- Lysosomal protective protein Source.151: DFBPPR20382 ---- Animal proteins ---- Ewing's tumor-associated antigen 1 homolog Source.152: DFBPPR20457 ---- Animal proteins ---- Neuropeptide Y receptor type 2 Source.153: DFBPPR20492 ---- Animal proteins ---- Microtubule-associated protein 10 Source.154: DFBPPR20555 ---- Animal proteins ---- Alpha/beta hydrolase domain-containing protein 17C Source.155: DFBPPR20617 ---- Animal proteins ---- GTPase-activating protein and VPS9 domain-containing protein 1 Source.156: DFBPPR20619 ---- Animal proteins ---- Extracellular matrix protein 2 Source.157: DFBPPR20626 ---- Animal proteins ---- Melanocortin receptor 5 Source.158: DFBPPR20665 ---- Animal proteins ---- PWWP domain-containing DNA repair factor 3A Source.159: DFBPPR20710 ---- Animal proteins ---- BMP/retinoic acid-inducible neural-specific protein 1 Source.160: DFBPPR20713 ---- Animal proteins ---- Golgi to ER traffic protein 4 homolog Source.161: DFBPPR20845 ---- Animal proteins ---- Solute carrier family 22 member 9 Source.162: DFBPPR20903 ---- Animal proteins ---- 40S ribosomal protein S3a Source.163: DFBPPR20907 ---- Animal proteins ---- Prostaglandin D2 receptor Source.164: DFBPPR21100 ---- Animal proteins ---- Cochlin Source.165: DFBPPR21181 ---- Animal proteins ---- Calpastatin Source.166: DFBPPR21198 ---- Animal proteins ---- Tax1-binding protein 1 homolog Source.167: DFBPPR21256 ---- Animal proteins ---- Eukaryotic translation initiation factor 4 gamma 2 Source.168: DFBPPR21340 ---- Animal proteins ---- Ribosome-releasing factor 2, mitochondrial Source.169: DFBPPR21357 ---- Animal proteins ---- Secretory carrier-associated membrane protein 3 Source.170: DFBPPR21421 ---- Animal proteins ---- Protein SMG8 Source.171: DFBPPR21484 ---- Animal proteins ---- Armadillo repeat-containing protein 8 Source.172: DFBPPR21525 ---- Animal proteins ---- AN1-type zinc finger protein 6 Source.173: DFBPPR21823 ---- Animal proteins ---- Zinc finger protein 526 Source.174: DFBPPR21849 ---- Animal proteins ---- ALS2 C-terminal-like protein Source.175: DFBPPR22034 ---- Animal proteins ---- Sugar phosphate exchanger 3 Source.176: DFBPPR22092 ---- Animal proteins ---- Kelch-like protein 36 Source.177: DFBPPR22154 ---- Animal proteins ---- Terminal nucleotidyltransferase 5B Source.178: DFBPPR22171 ---- Animal proteins ---- Leucine-rich repeat flightless-interacting protein 2 Source.179: DFBPPR22244 ---- Animal proteins ---- THAP domain-containing protein 3 Source.180: DFBPPR22300 ---- Animal proteins ---- S100P-binding protein Source.181: DFBPPR22481 ---- Animal proteins ---- Uncharacterized protein FAM241A Source.182: DFBPPR22673 ---- Animal proteins ---- Uncharacterized protein C7orf61 homolog Source.183: DFBPPR8558 ---- Animal proteins ---- Glycerophosphocholine cholinephosphodiesterase ENPP6 Source.184: DFBPPR8602 ---- Animal proteins ---- TGF-beta receptor type-2 Source.185: DFBPPR8635 ---- Animal proteins ---- Mu-type opioid receptor Source.186: DFBPPR8636 ---- Animal proteins ---- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Source.187: DFBPPR8684 ---- Animal proteins ---- Sialoadhesin Source.188: DFBPPR8696 ---- Animal proteins ---- Serine/threonine-protein phosphatase PP1-beta catalytic subunit Source.189: DFBPPR8732 ---- Animal proteins ---- Dihydropyrimidine dehydrogenase [NADP(+)] Source.190: DFBPPR8742 ---- Animal proteins ---- Low-density lipoprotein receptor-related protein 2 Source.191: DFBPPR8833 ---- Animal proteins ---- Pituitary adenylate cyclase-activating polypeptide Source.192: DFBPPR8971 ---- Animal proteins ---- Fibrillin-1 Source.193: DFBPPR9105 ---- Animal proteins ---- Lysine-specific demethylase 5C Source.194: DFBPPR9169 ---- Animal proteins ---- Aggrecan core protein Source.195: DFBPPR9205 ---- Animal proteins ---- Pulmonary surfactant-associated protein D Source.196: DFBPPR9354 ---- Animal proteins ---- D(1A) dopamine receptor Source.197: DFBPPR9396 ---- Animal proteins ---- GTP-binding protein SAR1b Source.198: DFBPPR9517 ---- Animal proteins ---- GTP-binding protein SAR1a Source.199: DFBPPR9566 ---- Animal proteins ---- Choline transporter-like protein 2 Source.200: DFBPPR9571 ---- Animal proteins ---- Neuropeptide Y receptor type 2 Source.201: DFBPPR9634 ---- Animal proteins ---- NADH-ubiquinone oxidoreductase chain 5 Source.202: DFBPPR9658 ---- Animal proteins ---- Melanocortin receptor 5 Source.203: DFBPPR9682 ---- Animal proteins ---- Cytidine monophosphate-N-acetylneuraminic acid hydroxylase Source.204: DFBPPR9956 ---- Animal proteins ---- Fatty acid synthase Source.205: DFBPPR9971 ---- Animal proteins ---- Ovotransferrin Source.206: DFBPPR9986 ---- Animal proteins ---- Aggrecan core protein Source.207: DFBPPR10173 ---- Animal proteins ---- Teneurin-1 Source.208: DFBPPR10188 ---- Animal proteins ---- Serine/threonine-protein phosphatase PP1-beta catalytic subunit Source.209: DFBPPR10190 ---- Animal proteins ---- TGF-beta receptor type-2 Source.210: DFBPPR10205 ---- Animal proteins ---- Noelin Source.211: DFBPPR10218 ---- Animal proteins ---- Occludin Source.212: DFBPPR10300 ---- Animal proteins ---- Unconventional myosin-Va Source.213: DFBPPR10381 ---- Animal proteins ---- ATP-dependent RNA helicase SUPV3L1, mitochondrial Source.214: DFBPPR10393 ---- Animal proteins ---- Vitellogenin-1 Source.215: DFBPPR10459 ---- Animal proteins ---- Reelin Source.216: DFBPPR10474 ---- Animal proteins ---- Serine/threonine-protein kinase greatwall Source.217: DFBPPR10538 ---- Animal proteins ---- Retinoblastoma-associated protein Source.218: DFBPPR10632 ---- Animal proteins ---- E3 ubiquitin-protein ligase Hakai Source.219: DFBPPR10656 ---- Animal proteins ---- BRCA1-A complex subunit Abraxas 1 Source.220: DFBPPR10729 ---- Animal proteins ---- Versican core protein Source.221: DFBPPR10801 ---- Animal proteins ---- Collagen alpha-1(VI) chain Source.222: DFBPPR10820 ---- Animal proteins ---- Collagen alpha-1(IX) chain Source.223: DFBPPR10832 ---- Animal proteins ---- BMP/retinoic acid-inducible neural-specific protein 1 Source.224: DFBPPR10896 ---- Animal proteins ---- Contactin-5 Source.225: DFBPPR10897 ---- Animal proteins ---- Doublesex- and mab-3-related transcription factor 1 Source.226: DFBPPR10912 ---- Animal proteins ---- Neurexin-3-beta Source.227: DFBPPR11114 ---- Animal proteins ---- E3 ubiquitin-protein ligase listerin Source.228: DFBPPR11138 ---- Animal proteins ---- Neuropeptide Y receptor type 2 Source.229: DFBPPR11221 ---- Animal proteins ---- Zinc finger homeobox protein 4 Source.230: DFBPPR11264 ---- Animal proteins ---- Charged multivesicular body protein 7 Source.231: DFBPPR11289 ---- Animal proteins ---- Alpha/beta hydrolase domain-containing protein 17C Source.232: DFBPPR11298 ---- Animal proteins ---- Transcription elongation factor SPT5 Source.233: DFBPPR11400 ---- Animal proteins ---- Thrombospondin-2 Source.234: DFBPPR11493 ---- Animal proteins ---- Interferon regulatory factor 1 Source.235: DFBPPR11824 ---- Animal proteins ---- DDB1- and CUL4-associated factor 13 Source.236: DFBPPR11876 ---- Animal proteins ---- Terminal nucleotidyltransferase 5C Source.237: DFBPPR11899 ---- Animal proteins ---- Protein ILRUN Source.238: DFBPPR11908 ---- Animal proteins ---- Centrosomal protein kizuna Source.239: DFBPPR12053 ---- Animal proteins ---- Sugar phosphate exchanger 3 Source.240: DFBPPR12216 ---- Animal proteins ---- 39S ribosomal protein L50, mitochondrial Source.241: DFBPPR12266 ---- Animal proteins ---- Serine/threonine-protein phosphatase PP1-alpha catalytic subunit Source.242: DFBPPR12289 ---- Animal proteins ---- Serine/threonine-protein phosphatase PP1-beta catalytic subunit Source.243: DFBPPR12506 ---- Animal proteins ---- Liver carboxylesterase 1 Source.244: DFBPPR12782 ---- Animal proteins ---- Eukaryotic translation initiation factor 4 gamma 2 Source.245: DFBPPR12794 ---- Animal proteins ---- Chloride channel protein 2 Source.246: DFBPPR12854 ---- Animal proteins ---- D(1A) dopamine receptor Source.247: DFBPPR12947 ---- Animal proteins ---- Aggrecan core protein Source.248: DFBPPR12988 ---- Animal proteins ---- Calpastatin Source.249: DFBPPR13091 ---- Animal proteins ---- Cortactin-binding protein 2 Source.250: DFBPPR13366 ---- Animal proteins ---- NADH-ubiquinone oxidoreductase chain 5 Source.251: DFBPPR13406 ---- Animal proteins ---- Cortactin-binding protein 2 Source.252: DFBPPR13610 ---- Animal proteins ---- Pituitary adenylate cyclase-activating polypeptide Source.253: DFBPPR13764 ---- Animal proteins ---- Mast cell protease 1A Source.254: DFBPPR13883 ---- Animal proteins ---- NADH-ubiquinone oxidoreductase chain 5 Source.255: DFBPPR13885 ---- Animal proteins ---- Mast cell protease 3 Source.256: DFBPPR13892 ---- Animal proteins ---- Melanocortin receptor 5 Source.257: DFBPPR13947 ---- Animal proteins ---- Cortactin-binding protein 2 Source.258: DFBPPR14097 ---- Marine protein ---- Katanin p60 ATPase-containing subunit A1 Source.259: DFBPPR14209 ---- Marine protein ---- 40S ribosomal protein S3a Source.260: DFBPPR14567 ---- Marine protein ---- C5a anaphylatoxin chemotactic receptor 1 Source.261: DFBPPR14729 ---- Marine protein ---- Protein LEG1 homolog Source.262: DFBPPR14968 ---- Microorganism protein ---- Small COPII coat GTPase SAR1 Source.263: DFBPPR15017 ---- Microorganism protein ---- Serine/threonine-protein kinase TEL1 Source.264: DFBPPR15047 ---- Microorganism protein ---- tRNA pseudouridine synthase 1 Source.265: DFBPPR15138 ---- Microorganism protein ---- GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase Source.266: DFBPPR15230 ---- Microorganism protein ---- Histone acetyltransferase type B subunit 2 Source.267: DFBPPR15370 ---- Microorganism protein ---- Mitochondrial division protein 1 Source.268: DFBPPR15499 ---- Microorganism protein ---- Mediator of RNA polymerase II transcription subunit 12 Source.269: DFBPPR7796 ---- Plant protein ---- NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic Source.270: DFBPPR7945 ---- Plant protein ---- NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic Source.271: DFBPPR8086 ---- Plant protein ---- NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic Source.272: DFBPPR8092 ---- Plant protein ---- Alpha-amylase inhibitor 2 Source.273: DFBPPR8250 ---- Plant protein ---- NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic Source.274: DFBPPR8256 ---- Plant protein ---- S-adenosylmethionine decarboxylase proenzyme
Link-research Inductive analysis	There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

ACE-inhibitory activity	The peptide showed very strong Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) inhibitory activity with an IC₅₀ value of 0.29 μM.
Specific target protein(s)	Specific Target Protein(s): Angiotensin-converting enzyme

Taste properties & Structure

Bitterness

Literature report	N.D
Bitter prediction tools	Non-bitter taste ^prediction

SMILES

N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CO)C(=O)O

Preparation method

Mode of preparation	Enzymatic hydrolysis
Enzyme(s)/starter culture	Tilapia muscle proteins were hydrolyzed by Virgibacillus halodenitrificans SK1-3-7 proteinases for up to 24 h.

Stability & Cytotoxicity

Peptide stability

Literature report:	N.D
EHP-Tool:	Enzymatic Hydrolysis Prediction Tool (EHP-Tool)

Peptide cytotoxicity

Literature report:	N.D
Prediction:	ToxinPred

Additional information

V. halodenitrificans SK1-3-7 proteinases-hydrolyzed tilapia mince could be a functional food ingredient containing ACE inhibitor peptides after in vitro gastrointestinal digestion and permeation across intestinal epithelial (Caco-2) cells.

Database cross-references

[D1]

[D2]

[D3]

[D4]

Reference(s)

Primary literature	Toopcham T, Mes JJ, Wichers HJ, Roytrakul S, Yongsawatdigul J. Bioavailability of angiotensin I-converting enzyme (ACE) inhibitory peptides derived from Virgibacillus halodenitrificans SK1-3-7 proteinases hydrolyzed tilapia muscle proteins. Food Chem. 2017 Apr 1;220:190-197. PMID: 27855889 DOI: 10.1016/j.foodchem.2016.09.183
Other literature(s)	N.D
PubDate	2017