Peptide properties

1Top 2Function-activity relationship 3Calculated physicochemical properties 4Peptide source & Food-borne protein(s) search 5Biological/Functional activity & target protein 6Taste properties & Structure 7Preparation method 8Stability & Cytotoxicity 9Additional information 10Database cross-references 11Reference(s)

List of peptide properties

DFBP ID - DFBPALGL0037(α-Glucosidase inhibitory peptide)

DFBP ID	DFBPALGL0037
Peptide sequence	PAVACCLPPLPCHM
Type	Native peptide
Peptide/Function name	α-Glucosidase inhibitory peptide, Anti-diabetic peptide

Function-activity relationship

Main bioactivity	α-Glucosidase inhibitory activity
Otheir bioactivity	α-Amylase inhibitory activity ^[D1], Multifunctional activity ^[D2]

Calculated physicochemical properties

Three-letter amino acid

Pro-Ala-Val-Ala-Cys-Cys-Leu-Pro-Pro-Leu-Pro-Cys-His-Met

Single-letter amino acid

PAVACCLPPLPCHM

Peptide length

Peptide mass

Experimental mass	Theoretical mass
N.D	1451.84 Da ^c

Net charge

0.00 ^c

Isoelectric point (pI)

6.89 ^c

IC₅₀

N.D

pIC₅₀

N.D

GRAVY

1.0857^c

Hydrophilic residue ratio

71.43%^c

Peptide calculator

Peptide source & Food-borne protein(s) search

Classification	Animal, Milk
Organism/Source	Camel (Camelus dromedaries)
Precursor protein	Whey protein hydrolysates
Residue position	N.D
Precursor protein(s) search	No matching precursor protein found
Link-research Inductive analysis	There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

α-Glucosidase inhibitory activity	Peptide PAVACCLPPLPCHM was dentified as potential inhibitors for both α-amylase and α-glucosidase (PepSite score > 0.8; http://pepsite2.russelllab.org/). IC₅₀ values for synthetic peptides not determined.
Specific target protein(s)	Specific Target Protein(s): Lysosomal alpha-glucosidase

Taste properties & Structure

Bitterness

Literature report	N.D
Bitter prediction tools	Bitter taste ^prediction

SMILES

N.D

Preparation method

Mode of preparation	Enzymatic hydrolysis
Enzyme(s)/starter culture	Camel whey protein was hydrolyzed with pepsin.

Stability & Cytotoxicity

Peptide stability

Literature report:	N.D
EHP-Tool:	Enzymatic Hydrolysis Prediction Tool (EHP-Tool)

Peptide cytotoxicity

Literature report:	N.D
Prediction:	ToxinPred

Additional information

N.D

Database cross-references

DFBP

[D1]	DFBPALAM0041
[D2]	DFBPMUFU0752

[D3]

[D4]

[D5]

[D6]

Reference(s)

Primary literature	Baba WN, Mudgil P, Kamal H, Kilari BP, Gan CY, Maqsood S. Identification and characterization of novel α-amylase and α-glucosidase inhibitory peptides from camel whey proteins. J Dairy Sci. 2021 Feb;104(2):1364-1377. PMID: 33309363 DOI: 10.3168/jds.2020-19271
Other literature(s)	N.D
PubDate	2021