The antihypertensive activity of each peptidic fraction obtained from the pearl oysters was evaluated by measuring the change in SBP at 1h, 2h, 3h, 4h, and 6h after oral administration. Systolic blood pressure did not change in the control rats during the experimental period (6 h). Captopril (10 mg/kg) lowered SBP significantly from 1 h to 4 h after administration of the drug. When the peptidic fraction from the pearl oyster was orally administered to the SHR, the fraction reduced SBP significantly by 45.9 mmHg at 3 h, and the antihypertensive effect continued for 4 h. The ACE-inhibitory peptide VEV was isolated from the highest active fraction, so the peptide was a potential antihypertensive peptide.
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