Peptide properties

1Top 2Function-activity relationship 3Calculated physicochemical properties 4Peptide source & Food-borne protein(s) search 5Biological/Functional activity & target protein 6Taste properties & Structure 7Preparation method 8Stability & Cytotoxicity 9Additional information 10Database cross-references 11Reference(s)

List of peptide properties

DFBP ID - DFBPOPIO0070(Opioid peptide)

DFBP ID	DFBPOPIO0070
Peptide sequence	GICACRRRFCPNSERFSGYCRVNGARYVRCCSRR
Type	Native peptide
Peptide/Function name	Opioid peptide, Corticostatin (CSI)

Function-activity relationship

Main bioactivity	Opioid activity
Otheir bioactivity	Antimicrobial activity ^[D1], Multifunctional activity ^[D2]

Calculated physicochemical properties

Three-letter amino acid

Gly-Ile-Cys-Ala-Cys-Arg-Arg-Arg-Phe-Cys-Pro-Asn-Ser-Glu-Arg-Phe-Ser-Gly-Tyr-Cys-Arg-Val-Asn-Gly-Ala-Arg-Tyr-Val-Arg-Cys-Cys-Ser-Arg-Arg

Single-letter amino acid

GICACRRRFCPNSERFSGYCRVNGARYVRCCSRR

Peptide length

Peptide mass

Experimental mass	Theoretical mass
N.D	4003.65 Da ^c

Net charge

0.00 ^c

Isoelectric point (pI)

10.25 ^c

IC₅₀

N.D

pIC₅₀

N.D

GRAVY

-0.6382^c

Hydrophilic residue ratio

32.35%^c

Peptide calculator

Peptide source & Food-borne protein(s) search

Classification	Animal
Organism/Source	Rabbit
Precursor protein	Adult rabbit lung
Residue position	N.D
Precursor protein(s) search	Source.1: DFBPPR12880 ---- Animal proteins ---- Corticostatin 1
Link-research Inductive analysis	There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

Opioid activity	Corticostatin showed opioid activity (data not shown).
Specific target protein(s)	N.D

Taste properties & Structure

Bitterness

Literature report	N.D
Bitter prediction tools	Non-bitter taste ^prediction

SMILES

NCC(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CS)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O

Preparation method

Mode of preparation	Extracting without enzyme
Enzyme(s)/starter culture	No enzyme

Stability & Cytotoxicity

Peptide stability

Literature report:	N.D
EHP-Tool:	Enzymatic Hydrolysis Prediction Tool (EHP-Tool)

Peptide cytotoxicity

Literature report:	N.D
Prediction:	ToxinPred

Additional information

Corticostatin have previously been isolated from rabbit peritoneal neutrophils and alveolar macrophages and found to be antiviral and antimicrobial agents ^[1].

Database cross-references

DFBP

[D1]	DFBPAMIC0054
[D2]	DFBPMUFU0700

[D3]

[D4]

[D5]

[D6]

Reference(s)

Primary literature	Zhu QZ, Hu J, Mulay S, Esch F, Shimasaki S, Solomon S. Isolation and structure of corticostatin peptides from rabbit fetal and adult lung. Proc Natl Acad Sci U S A. 1988 Jan;85(2):592-6. PMID: 2829194 DOI: 10.1073/pnas.85.2.592
Other literature(s)	[1] Selsted M E, Brown D M, Delange R J, et al. Primary structures of six antimicrobial peptides of rabbit peritoneal neutrophils.[J]. Journal of Biological Chemistry, 1985, 260(8):4579-84.
PubDate	1988