DFBP ID - DFBPACEI0383(ACE-inhibitory peptide) |
DFBP ID |
DFBPACEI0383 |
Peptide sequence |
IYP |
Type |
Native peptide |
Peptide/Function name |
ACE-inhibitory peptide |
|
Function-activity relationship |
Main bioactivity |
ACE-inhibitory activity |
Otheir bioactivity |
PEP-inhibitory activity [D1], Multifunctional activity [D2] |
|
Calculated physicochemical properties |
Three-letter amino acid |
Ile-Tyr-Pro |
Single-letter amino acid |
IYP |
Peptide length |
3 |
Peptide mass |
Experimental mass |
Theoretical mass |
N.D |
391.46 Da c |
|
Net charge |
0.00 c |
Isoelectric point (pI) |
5.92 c |
IC50 |
61 μM
|
pIC50 |
-1.785 |
GRAVY |
0.5333 c |
Hydrophilic residue ratio |
66.67% c |
Peptide calculator |
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|
Biological/Functional activity & target protein |
ACE-inhibitory activity |
The peptide exhibited potent Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) inhibitory activity with an IC50
value of 61 uM. |
Specific target protein(s) |
Specific Target Protein(s): Angiotensin-converting enzyme |
|
Taste properties & Structure |
Bitterness |
Literature report |
N.D |
Bitter prediction tools |
Bitter taste prediction |
|
SMILES |
N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1[C@@]([H])(CCC1)C(=O)O |
|
Preparation method |
Mode of preparation |
Synthesis
|
Enzyme(s)/starter culture |
The peptides used in this study were synthesized by the solid-phase method. |
|
Stability & Cytotoxicity |
Peptide stability |
|
Peptide cytotoxicity |
|
|
Additional information |
Additional information |
N.D |
|
Database cross-references |
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Reference(s) |
Primary literature |
Kohmura, M., Nio, N., Kubo, K., Minoshima, Y., Munekata, E., Ariyoshi, Y. Inhibition of Angiotensin-converting Enzyme by Synthetic Peptides of Human β-Casein. Agricultural and Biological Chemistry. 2014, 53, 2107-14.
|
Other literature(s) |
N.D |
PubDate |
2014 |
|