Peptide properties

1Top 2Function-activity relationship 3Calculated physicochemical properties 4Peptide source & Food-borne protein(s) search 5Biological/Functional activity & target protein 6Taste properties & Structure 7Preparation method 8Stability & Cytotoxicity 9Additional information 10Database cross-references 11Reference(s)

List of peptide properties

DFBP ID - DFBPALGL0023(α-Glucosidase inhibitory peptide)

DFBP ID	DFBPALGL0023
Peptide sequence	YPY
Type	Native peptide
Peptide/Function name	α-Glucosidase inhibitory peptide, Anti-diabetic peptide

Function-activity relationship

Main bioactivity	α-Glucosidase inhibitory activity
Otheir bioactivity	DPP IV-inhibitory activity ^[D1], Opioid activity ^[D2], Multifunctional activity ^[D3]

Calculated physicochemical properties

Three-letter amino acid

Tyr-Pro-Tyr

Single-letter amino acid

YPY

Peptide length

Peptide mass

Experimental mass	Theoretical mass
N.D	441.48 Da ^c

Net charge

0.00 ^c

Isoelectric point (pI)

5.87 ^c

IC₅₀

N.D

pIC₅₀

N.D

GRAVY

-1.4000^c

Hydrophilic residue ratio

33.33%^c

Peptide calculator

Peptide source & Food-borne protein(s) search

Classification	Animal, Fish, Marine
Organism/Source	Sardine
Precursor protein	Muscle protein hydrolyzates
Residue position	N.D
Precursor protein(s) search	Source.1: DFBPPR0838 ---- Plant proteins ---- Glucose-1-phosphate adenylyltransferase large subunit 2, cytosolic Source.2: DFBPPR0855 ---- Plant proteins ---- LRR receptor kinase BAK1 Source.3: DFBPPR0871 ---- Plant proteins ---- LRR receptor kinase SERK2 Source.4: DFBPPR0875 ---- Plant proteins ---- ABC transporter G family member 5 Source.5: DFBPPR0935 ---- Plant proteins ---- Cytochrome P450 724B1 Source.6: DFBPPR0957 ---- Plant proteins ---- Beta-glucosidase 26 Source.7: DFBPPR1068 ---- Plant proteins ---- E3 ubiquitin-protein ligase DIS1 Source.8: DFBPPR1082 ---- Plant proteins ---- DNA polymerase alpha catalytic subunit Source.9: DFBPPR1285 ---- Plant proteins ---- LRR receptor kinase SERK2 Source.10: DFBPPR1348 ---- Plant proteins ---- Cytochrome b Source.11: DFBPPR1379 ---- Plant proteins ---- 1-deoxy-D-xylulose-5-phosphate synthase 1, chloroplastic Source.12: DFBPPR1392 ---- Plant proteins ---- Isocitrate lyase Source.13: DFBPPR1441 ---- Plant proteins ---- Cysteine protease 1 Source.14: DFBPPR1458 ---- Plant proteins ---- Endoglucanase 9 Source.15: DFBPPR1478 ---- Plant proteins ---- Linoleate 9S-lipoxygenase 2 Source.16: DFBPPR1502 ---- Plant proteins ---- Nuclear transcription factor Y subunit C-4 Source.17: DFBPPR1532 ---- Plant proteins ---- Senescence-specific cysteine protease SAG39 Source.18: DFBPPR1535 ---- Plant proteins ---- Photosystem I P700 chlorophyll a apoprotein A1 Source.19: DFBPPR1613 ---- Plant proteins ---- Villin-3 Source.20: DFBPPR1730 ---- Plant proteins ---- DNA repair and recombination protein RAD54 Source.21: DFBPPR1777 ---- Plant proteins ---- Probable serine/threonine-protein kinase WNK1 Source.22: DFBPPR1916 ---- Plant proteins ---- Protein PYRICULARIA ORYZAE RESISTANCE 21 Source.23: DFBPPR1923 ---- Plant proteins ---- Probable serine/threonine-protein kinase WNK2 Source.24: DFBPPR1996 ---- Plant proteins ---- Transcription initiation factor IIB Source.25: DFBPPR2060 ---- Plant proteins ---- CBL-interacting protein kinase 3 Source.26: DFBPPR2064 ---- Plant proteins ---- Linoleate 9S-lipoxygenase 1 Source.27: DFBPPR2132 ---- Plant proteins ---- Oryzain beta chain Source.28: DFBPPR2159 ---- Plant proteins ---- NAD(P)H-quinone oxidoreductase subunit I, chloroplastic Source.29: DFBPPR2161 ---- Plant proteins ---- Probable serine/threonine-protein kinase WNK7 Source.30: DFBPPR2200 ---- Plant proteins ---- COBRA-like protein 5 Source.31: DFBPPR2212 ---- Plant proteins ---- BURP domain-containing protein 13 Source.32: DFBPPR2271 ---- Plant proteins ---- Probable serine/threonine-protein kinase WNK3 Source.33: DFBPPR2330 ---- Plant proteins ---- Probable staphylococcal-like nuclease CAN3 Source.34: DFBPPR2351 ---- Plant proteins ---- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit Source.35: DFBPPR2394 ---- Plant proteins ---- Sucrose synthase 5 Source.36: DFBPPR2413 ---- Plant proteins ---- Probable serine/threonine-protein kinase WNK8 Source.37: DFBPPR2417 ---- Plant proteins ---- Probable serine/threonine-protein kinase WNK4 Source.38: DFBPPR2443 ---- Plant proteins ---- Oryzain alpha chain Source.39: DFBPPR2528 ---- Plant proteins ---- Probable staphylococcal-like nuclease CAN2 Source.40: DFBPPR2570 ---- Plant proteins ---- Endoglucanase 12 Source.41: DFBPPR2668 ---- Plant proteins ---- Two-component response regulator ORR33 Source.42: DFBPPR2693 ---- Plant proteins ---- Parkeol synthase Source.43: DFBPPR2707 ---- Plant proteins ---- Probable serine/threonine-protein kinase WNK9 Source.44: DFBPPR2911 ---- Plant proteins ---- Probable V-type proton ATPase subunit d Source.45: DFBPPR2967 ---- Plant proteins ---- Sucrose synthase 7 Source.46: DFBPPR3077 ---- Plant proteins ---- ABC transporter G family member 31 Source.47: DFBPPR3082 ---- Plant proteins ---- 4-alpha-glucanotransferase DPE2 Source.48: DFBPPR3118 ---- Plant proteins ---- DNA polymerase delta small subunit Source.49: DFBPPR3141 ---- Plant proteins ---- Multicopper oxidase LPR1 homolog 1 Source.50: DFBPPR3186 ---- Plant proteins ---- Endoglucanase 10 Source.51: DFBPPR3218 ---- Plant proteins ---- Probable lipoxygenase 6 Source.52: DFBPPR3227 ---- Plant proteins ---- Oryzain gamma chain Source.53: DFBPPR3255 ---- Plant proteins ---- COBRA-like protein 6 Source.54: DFBPPR3360 ---- Plant proteins ---- Cycloartenol synthase Source.55: DFBPPR3445 ---- Plant proteins ---- Serine/threonine-protein kinase ATR Source.56: DFBPPR3517 ---- Plant proteins ---- Triose phosphate/phosphate translocator TPT, chloroplastic Source.57: DFBPPR3632 ---- Plant proteins ---- Probable linoleate 9S-lipoxygenase 4 Source.58: DFBPPR3638 ---- Plant proteins ---- 4-coumarate--CoA ligase-like 6 Source.59: DFBPPR3648 ---- Plant proteins ---- Putative lipoxygenase 5 Source.60: DFBPPR3671 ---- Plant proteins ---- Putative linoleate 9S-lipoxygenase 3 Source.61: DFBPPR3727 ---- Plant proteins ---- Serine decarboxylase 1 Source.62: DFBPPR3730 ---- Plant proteins ---- 50S ribosomal protein L27, chloroplastic Source.63: DFBPPR3970 ---- Plant proteins ---- Ribonuclease 3-like protein 3 Source.64: DFBPPR4075 ---- Plant proteins ---- Villin-4 Source.65: DFBPPR4093 ---- Plant proteins ---- Villin-5 Source.66: DFBPPR4257 ---- Plant proteins ---- Probable metal-nicotianamine transporter YSL4 Source.67: DFBPPR4278 ---- Plant proteins ---- Calcium-binding protein CBP Source.68: DFBPPR4335 ---- Plant proteins ---- Actin-related protein 5 Source.69: DFBPPR4380 ---- Plant proteins ---- Sucrose synthase 6 Source.70: DFBPPR4607 ---- Plant proteins ---- Protein LOL2 Source.71: DFBPPR4610 ---- Plant proteins ---- Protein LOL3 Source.72: DFBPPR4684 ---- Plant proteins ---- BURP domain-containing protein 17 Source.73: DFBPPR4732 ---- Plant proteins ---- BURP domain-containing protein 5 Source.74: DFBPPR4745 ---- Plant proteins ---- BURP domain-containing protein 9 Source.75: DFBPPR4748 ---- Plant proteins ---- BURP domain-containing protein 11 Source.76: DFBPPR4834 ---- Plant proteins ---- Zinc finger CCCH domain-containing protein 66 Source.77: DFBPPR4877 ---- Plant proteins ---- Putative B3 domain-containing protein Os08g0333500 Source.78: DFBPPR4968 ---- Plant proteins ---- Seed linoleate 13S-lipoxygenase-1 Source.79: DFBPPR4979 ---- Plant proteins ---- Seed linoleate 9S-lipoxygenase-3 Source.80: DFBPPR4991 ---- Plant proteins ---- Seed linoleate 9S-lipoxygenase Source.81: DFBPPR4997 ---- Plant proteins ---- P34 probable thiol protease Source.82: DFBPPR5005 ---- Plant proteins ---- Linoleate 9S-lipoxygenase-4 Source.83: DFBPPR5011 ---- Plant proteins ---- Diacylglycerol O-acyltransferase 1A Source.84: DFBPPR5014 ---- Plant proteins ---- Glycinol 4-dimethylallyltransferase Source.85: DFBPPR5018 ---- Plant proteins ---- Guanine nucleotide-binding protein alpha-2 subunit Source.86: DFBPPR5034 ---- Plant proteins ---- 15-cis-phytoene desaturase, chloroplastic/chromoplastic Source.87: DFBPPR5037 ---- Plant proteins ---- Seed linoleate 9S-lipoxygenase-2 Source.88: DFBPPR5042 ---- Plant proteins ---- Diacylglycerol O-acyltransferase 1B Source.89: DFBPPR5047 ---- Plant proteins ---- Photosystem I P700 chlorophyll a apoprotein A1 Source.90: DFBPPR5075 ---- Plant proteins ---- DNA polymerase delta catalytic subunit Source.91: DFBPPR5096 ---- Plant proteins ---- Isocitrate lyase 2 Source.92: DFBPPR5098 ---- Plant proteins ---- Isocitrate lyase 1 Source.93: DFBPPR5122 ---- Plant proteins ---- NAD(P)H-quinone oxidoreductase subunit I, chloroplastic Source.94: DFBPPR5195 ---- Plant proteins ---- Diacylglycerol O-acyltransferase 1C Source.95: DFBPPR5217 ---- Plant proteins ---- Soyasaponin III rhamnosyltransferase Source.96: DFBPPR5245 ---- Plant proteins ---- Omega-6 fatty acid desaturase, chloroplastic Source.97: DFBPPR5306 ---- Plant proteins ---- Glucan endo-1,3-beta-glucosidase Source.98: DFBPPR5448 ---- Plant proteins ---- Glucose-1-phosphate adenylyltransferase large subunit 1, chloroplastic/amyloplastic Source.99: DFBPPR5480 ---- Plant proteins ---- Glucose-1-phosphate adenylyltransferase large subunit 2, chloroplastic/amyloplastic Source.100: DFBPPR5549 ---- Plant proteins ---- 3-deoxy-manno-octulosonate cytidylyltransferase Source.101: DFBPPR5563 ---- Plant proteins ---- Photosystem I P700 chlorophyll a apoprotein A1 Source.102: DFBPPR5602 ---- Plant proteins ---- Ribosome-inactivating protein 3 Source.103: DFBPPR5624 ---- Plant proteins ---- Ribosome-inactivating protein 9 Source.104: DFBPPR5643 ---- Plant proteins ---- Triose phosphate/phosphate translocator, chloroplastic Source.105: DFBPPR5661 ---- Plant proteins ---- Albumin b-32 Source.106: DFBPPR5669 ---- Plant proteins ---- Cytochrome b Source.107: DFBPPR5677 ---- Plant proteins ---- Ribosome-inactivating protein Source.108: DFBPPR5741 ---- Plant proteins ---- NAD(P)H-quinone oxidoreductase subunit I, chloroplastic Source.109: DFBPPR5756 ---- Plant proteins ---- Glucan endo-1,3-beta-glucosidase, acidic isoform Source.110: DFBPPR5764 ---- Plant proteins ---- Cysteine proteinase 1 Source.111: DFBPPR5857 ---- Plant proteins ---- Sucrose synthase 1 Source.112: DFBPPR6008 ---- Plant proteins ---- Zein-beta Source.113: DFBPPR6208 ---- Plant proteins ---- Cysteine proteinase 2 Source.114: DFBPPR6274 ---- Plant proteins ---- Photosystem I P700 chlorophyll a apoprotein A1 Source.115: DFBPPR6292 ---- Plant proteins ---- Probable ion channel SYM8 Source.116: DFBPPR6309 ---- Plant proteins ---- Cytochrome b Source.117: DFBPPR6314 ---- Plant proteins ---- Protein TIC 40, chloroplastic Source.118: DFBPPR6318 ---- Plant proteins ---- Glucan endo-1,3-beta-glucosidase Source.119: DFBPPR6334 ---- Plant proteins ---- Triose phosphate/phosphate translocator, chloroplastic Source.120: DFBPPR6370 ---- Plant proteins ---- Seed linoleate 9S-lipoxygenase-3 Source.121: DFBPPR6371 ---- Plant proteins ---- Seed linoleate 9S-lipoxygenase-2 Source.122: DFBPPR6538 ---- Plant proteins ---- Translationally-controlled tumor protein homolog Source.123: DFBPPR6638 ---- Plant proteins ---- Glucose-1-phosphate adenylyltransferase large subunit, chloroplastic/amyloplastic Source.124: DFBPPR6649 ---- Plant proteins ---- Glucose-1-phosphate adenylyltransferase large subunit, chloroplastic/amyloplastic Source.125: DFBPPR6668 ---- Plant proteins ---- Cytochrome b Source.126: DFBPPR6696 ---- Plant proteins ---- Photosystem I P700 chlorophyll a apoprotein A1 Source.127: DFBPPR6723 ---- Plant proteins ---- Ubiquitin-conjugating enzyme E2-23 kDa Source.128: DFBPPR6733 ---- Plant proteins ---- NAD(P)H-quinone oxidoreductase subunit I, chloroplastic Source.129: DFBPPR6755 ---- Plant proteins ---- Glucan endo-1,3-beta-glucosidase Source.130: DFBPPR6824 ---- Plant proteins ---- Protein RAFTIN 1B Source.131: DFBPPR6845 ---- Plant proteins ---- Protein RAFTIN 1A Source.132: DFBPPR7018 ---- Plant proteins ---- Glucose-1-phosphate adenylyltransferase large subunit 1, chloroplastic/amyloplastic Source.133: DFBPPR7021 ---- Plant proteins ---- Lipoxygenase 2.1, chloroplastic Source.134: DFBPPR7025 ---- Plant proteins ---- Glucose-1-phosphate adenylyltransferase large subunit 2 Source.135: DFBPPR7033 ---- Plant proteins ---- Lipoxygenase 2.3, chloroplastic Source.136: DFBPPR7040 ---- Plant proteins ---- Linoleate 9S-lipoxygenase 1 Source.137: DFBPPR7042 ---- Plant proteins ---- Glucan endo-1,3-beta-glucosidase GII Source.138: DFBPPR7050 ---- Plant proteins ---- Lichenase-2 Source.139: DFBPPR7065 ---- Plant proteins ---- Photosystem I P700 chlorophyll a apoprotein A1 Source.140: DFBPPR7067 ---- Plant proteins ---- Glucan endo-1,3-beta-glucosidase GI Source.141: DFBPPR7083 ---- Plant proteins ---- Lipoxygenase 2.2, chloroplastic Source.142: DFBPPR7110 ---- Plant proteins ---- Glucan endo-1,3-beta-glucosidase GIII Source.143: DFBPPR7133 ---- Plant proteins ---- NAD(P)H-quinone oxidoreductase subunit I, chloroplastic Source.144: DFBPPR7136 ---- Plant proteins ---- Glucan endo-1,3-beta-glucosidase GIV Source.145: DFBPPR7176 ---- Plant proteins ---- Glucan endo-1,3-beta-glucosidase GV Source.146: DFBPPR7181 ---- Plant proteins ---- Putative glucan endo-1,3-beta-glucosidase GVI Source.147: DFBPPR7204 ---- Plant proteins ---- Thiol protease aleurain Source.148: DFBPPR7241 ---- Plant proteins ---- Cysteine proteinase EP-B 2 Source.149: DFBPPR7249 ---- Plant proteins ---- Cysteine proteinase EP-B 1 Source.150: DFBPPR7428 ---- Plant proteins ---- Isocitrate lyase Source.151: DFBPPR7490 ---- Plant proteins ---- Cysteine proteinase COT44 Source.152: DFBPPR7503 ---- Plant proteins ---- Omega-6 fatty acid desaturase, chloroplastic Source.153: DFBPPR7521 ---- Plant proteins ---- BURP domain-containing protein BNM2A Source.154: DFBPPR7531 ---- Plant proteins ---- BURP domain-containing protein BNM2C Source.155: DFBPPR7601 ---- Milk proteins ---- Lactoperoxidase Source.156: DFBPPR7602 ---- Milk proteins ---- Alpha-S1-casein Source.157: DFBPPR7607 ---- Milk proteins ---- Galectin-3-binding protein Source.158: DFBPPR7608 ---- Milk proteins ---- Kappa-casein Source.159: DFBPPR7623 ---- Milk proteins ---- Platelet glycoprotein 4 Source.160: DFBPPR7637 ---- Milk proteins ---- Perilipin-2 Source.161: DFBPPR7668 ---- Milk proteins ---- Beta-casein Source.162: DFBPPR7686 ---- Milk proteins ---- Kappa-casein Source.163: DFBPPR7689 ---- Milk proteins ---- Alpha-S2-casein Source.164: DFBPPR7695 ---- Milk proteins ---- Kappa-casein Source.165: DFBPPR7715 ---- Milk proteins ---- Kappa-casein Source.166: DFBPPR8195 ---- Plant proteins ---- Isocitrate lyase Source.167: DFBPPR8430 ---- Plant proteins ---- NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic Source.168: DFBPPR8437 ---- Plant proteins ---- Linoleate 9S-lipoxygenase Source.169: DFBPPR8492 ---- Milk proteins ---- Kappa-casein Source.170: DFBPPR8501 ---- Milk proteins ---- Platelet glycoprotein 4 Source.171: DFBPPR8523 ---- Milk proteins ---- Perilipin-2 Source.172: DFBPPR15953 ---- Animal proteins ---- Occludin Source.173: DFBPPR16082 ---- Animal proteins ---- Ras-related protein Rab-9A Source.174: DFBPPR16084 ---- Animal proteins ---- T-box transcription factor TBX2 Source.175: DFBPPR16086 ---- Animal proteins ---- Sodium/potassium-transporting ATPase subunit beta-1 Source.176: DFBPPR16093 ---- Animal proteins ---- Menin Source.177: DFBPPR16142 ---- Animal proteins ---- Procathepsin L Source.178: DFBPPR16181 ---- Animal proteins ---- Inositol polyphosphate-5-phosphatase A Source.179: DFBPPR16190 ---- Animal proteins ---- Aprataxin Source.180: DFBPPR16211 ---- Animal proteins ---- Lysine-specific demethylase 5C Source.181: DFBPPR16232 ---- Animal proteins ---- Lysine-specific demethylase 5D Source.182: DFBPPR16254 ---- Animal proteins ---- Transferrin receptor protein 1 Source.183: DFBPPR16300 ---- Animal proteins ---- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit Source.184: DFBPPR16304 ---- Animal proteins ---- Cathepsin K Source.185: DFBPPR16314 ---- Animal proteins ---- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase Source.186: DFBPPR16462 ---- Animal proteins ---- Pantetheinase Source.187: DFBPPR16477 ---- Animal proteins ---- Beta-glucuronidase Source.188: DFBPPR16479 ---- Animal proteins ---- Carboxypeptidase B Source.189: DFBPPR16485 ---- Animal proteins ---- Cathepsin S Source.190: DFBPPR16581 ---- Animal proteins ---- NADH-ubiquinone oxidoreductase chain 5 Source.191: DFBPPR16646 ---- Animal proteins ---- AT-rich interactive domain-containing protein 5B Source.192: DFBPPR16712 ---- Animal proteins ---- RNA-binding protein 47 Source.193: DFBPPR16745 ---- Animal proteins ---- Ig kappa chain V region GOM Source.194: DFBPPR16811 ---- Animal proteins ---- Carboxypeptidase A1 Source.195: DFBPPR16894 ---- Animal proteins ---- Procathepsin L Source.196: DFBPPR17095 ---- Animal proteins ---- Hyaluronidase-1 Source.197: DFBPPR17364 ---- Animal proteins ---- Pro-cathepsin H Source.198: DFBPPR17379 ---- Animal proteins ---- Dematin Source.199: DFBPPR17406 ---- Animal proteins ---- Exostosin-2 Source.200: DFBPPR17507 ---- Animal proteins ---- Interferon alpha/beta receptor 1 Source.201: DFBPPR17533 ---- Animal proteins ---- Carboxypeptidase E Source.202: DFBPPR17547 ---- Animal proteins ---- Cleavage and polyadenylation specificity factor subunit 5 Source.203: DFBPPR17576 ---- Animal proteins ---- Fibrillin-1 Source.204: DFBPPR17759 ---- Animal proteins ---- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase Source.205: DFBPPR17781 ---- Animal proteins ---- Ubiquitin-conjugating enzyme E2 C Source.206: DFBPPR17849 ---- Animal proteins ---- Fibromodulin Source.207: DFBPPR17879 ---- Animal proteins ---- Menin Source.208: DFBPPR17893 ---- Animal proteins ---- Inositol 1,4,5-trisphosphate receptor type 3 Source.209: DFBPPR18013 ---- Animal proteins ---- Syntaxin-binding protein 1 Source.210: DFBPPR18060 ---- Animal proteins ---- 2',5'-phosphodiesterase 12 Source.211: DFBPPR18075 ---- Animal proteins ---- ATP synthase subunit d, mitochondrial Source.212: DFBPPR18088 ---- Animal proteins ---- Aprataxin Source.213: DFBPPR18099 ---- Animal proteins ---- Transcription factor NF-E2 45 kDa subunit Source.214: DFBPPR18142 ---- Animal proteins ---- Protein CASC3 Source.215: DFBPPR18235 ---- Animal proteins ---- Neuronal acetylcholine receptor subunit alpha-5 Source.216: DFBPPR18276 ---- Animal proteins ---- 2-hydroxyacyl-CoA lyase 2 Source.217: DFBPPR18350 ---- Animal proteins ---- BRISC and BRCA1-A complex member 2 Source.218: DFBPPR18464 ---- Animal proteins ---- Regucalcin Source.219: DFBPPR18467 ---- Animal proteins ---- Alpha-aminoadipic semialdehyde synthase, mitochondrial Source.220: DFBPPR18534 ---- Animal proteins ---- M-phase inducer phosphatase 3 Source.221: DFBPPR18535 ---- Animal proteins ---- M-phase inducer phosphatase 1 Source.222: DFBPPR18539 ---- Animal proteins ---- Dermatan-sulfate epimerase Source.223: DFBPPR18566 ---- Animal proteins ---- Cytochrome c oxidase subunit 5A, mitochondrial Source.224: DFBPPR18571 ---- Animal proteins ---- CREB-regulated transcription coactivator 2 Source.225: DFBPPR18720 ---- Animal proteins ---- Protein quaking Source.226: DFBPPR18777 ---- Animal proteins ---- Interleukin-1 receptor-associated kinase-like 2 Source.227: DFBPPR18780 ---- Animal proteins ---- Homeobox protein Hox-A3 Source.228: DFBPPR18815 ---- Animal proteins ---- Pantetheinase Source.229: DFBPPR18843 ---- Animal proteins ---- Carboxypeptidase B Source.230: DFBPPR18901 ---- Animal proteins ---- Nuclear factor of activated T-cells, cytoplasmic 1 Source.231: DFBPPR18973 ---- Animal proteins ---- Transcriptional activator Myb Source.232: DFBPPR18976 ---- Animal proteins ---- Tumor suppressor candidate 3 Source.233: DFBPPR18988 ---- Animal proteins ---- Lysosomal Pro-X carboxypeptidase Source.234: DFBPPR19063 ---- Animal proteins ---- Asparagine synthetase [glutamine-hydrolyzing] Source.235: DFBPPR19119 ---- Animal proteins ---- Phospholipase D2 Source.236: DFBPPR19195 ---- Animal proteins ---- V-type proton ATPase 116 kDa subunit a2 Source.237: DFBPPR19264 ---- Animal proteins ---- Claudin-16 Source.238: DFBPPR19285 ---- Animal proteins ---- Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial Source.239: DFBPPR19299 ---- Animal proteins ---- Annexin A7 Source.240: DFBPPR19370 ---- Animal proteins ---- Neuroendocrine convertase 2 Source.241: DFBPPR19478 ---- Animal proteins ---- Carboxypeptidase N catalytic chain Source.242: DFBPPR19500 ---- Animal proteins ---- Complement C2 Source.243: DFBPPR19730 ---- Animal proteins ---- Tensin-1 Source.244: DFBPPR19738 ---- Animal proteins ---- Translocator protein Source.245: DFBPPR19766 ---- Animal proteins ---- V-type proton ATPase subunit C 1 Source.246: DFBPPR19848 ---- Animal proteins ---- Endoplasmic reticulum resident protein 29 Source.247: DFBPPR19908 ---- Animal proteins ---- DNA replication licensing factor MCM6 Source.248: DFBPPR19913 ---- Animal proteins ---- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial Source.249: DFBPPR19939 ---- Animal proteins ---- Phosphatidylinositol transfer protein beta isoform Source.250: DFBPPR20011 ---- Animal proteins ---- E3 ubiquitin-protein ligase TRIM17 Source.251: DFBPPR20119 ---- Animal proteins ---- Cathepsin L2 Source.252: DFBPPR20212 ---- Animal proteins ---- Outer dense fiber protein 1 Source.253: DFBPPR20277 ---- Animal proteins ---- Transmembrane protein 214 Source.254: DFBPPR20361 ---- Animal proteins ---- Cation channel sperm-associated protein subunit delta Source.255: DFBPPR20369 ---- Animal proteins ---- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 Source.256: DFBPPR20562 ---- Animal proteins ---- 12S rRNA N4-methylcytidine methyltransferase Source.257: DFBPPR20744 ---- Animal proteins ---- Phosphatidylinositol transfer protein alpha isoform Source.258: DFBPPR20798 ---- Animal proteins ---- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit Source.259: DFBPPR20839 ---- Animal proteins ---- Cysteine-rich secretory protein LCCL domain-containing 2 Source.260: DFBPPR20914 ---- Animal proteins ---- AT-rich interactive domain-containing protein 5B Source.261: DFBPPR20963 ---- Animal proteins ---- Protein kintoun Source.262: DFBPPR21037 ---- Animal proteins ---- Zinc finger protein 574 Source.263: DFBPPR21055 ---- Animal proteins ---- 39S ribosomal protein L37, mitochondrial Source.264: DFBPPR21075 ---- Animal proteins ---- Constitutive coactivator of PPAR-gamma-like protein 1 Source.265: DFBPPR21222 ---- Animal proteins ---- Cytosolic carboxypeptidase 3 Source.266: DFBPPR21228 ---- Animal proteins ---- Inactive hydroxysteroid dehydrogenase-like protein 1 Source.267: DFBPPR21262 ---- Animal proteins ---- Probable tRNA methyltransferase 9B Source.268: DFBPPR21306 ---- Animal proteins ---- Protein ATP1B4 Source.269: DFBPPR21432 ---- Animal proteins ---- Amelogenin, Y isoform Source.270: DFBPPR21447 ---- Animal proteins ---- Transmembrane protein 39A Source.271: DFBPPR21563 ---- Animal proteins ---- RWD domain-containing protein 3 Source.272: DFBPPR21690 ---- Animal proteins ---- Synapse differentiation-inducing gene protein 1-like Source.273: DFBPPR21796 ---- Animal proteins ---- snRNA-activating protein complex subunit 3 Source.274: DFBPPR21878 ---- Animal proteins ---- Statherin Source.275: DFBPPR21975 ---- Animal proteins ---- Protein AAR2 homolog Source.276: DFBPPR21976 ---- Animal proteins ---- COMM domain-containing protein 6 Source.277: DFBPPR21980 ---- Animal proteins ---- Suppressor of tumorigenicity 7 protein Source.278: DFBPPR22072 ---- Animal proteins ---- Brain protein I3 Source.279: DFBPPR22089 ---- Animal proteins ---- N-myc-interactor Source.280: DFBPPR22302 ---- Animal proteins ---- Protein angel homolog 2 Source.281: DFBPPR22331 ---- Animal proteins ---- Zinc finger SWIM domain-containing protein 8 Source.282: DFBPPR22428 ---- Animal proteins ---- Cysteine-rich and transmembrane domain-containing protein 1 Source.283: DFBPPR22503 ---- Animal proteins ---- Suppressor of tumorigenicity 7 protein-like Source.284: DFBPPR22644 ---- Animal proteins ---- BTB/POZ domain-containing protein KCTD18 Source.285: DFBPPR8527 ---- Animal proteins ---- Tumor necrosis factor ligand superfamily member 6 Source.286: DFBPPR8538 ---- Animal proteins ---- Sodium/potassium-transporting ATPase subunit beta-1 Source.287: DFBPPR8567 ---- Animal proteins ---- CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 Source.288: DFBPPR8613 ---- Animal proteins ---- Thyroglobulin Source.289: DFBPPR8641 ---- Animal proteins ---- Phospholipid phosphatase 1 Source.290: DFBPPR8735 ---- Animal proteins ---- Pro-cathepsin H Source.291: DFBPPR8745 ---- Animal proteins ---- Hyaluronidase-1 Source.292: DFBPPR8776 ---- Animal proteins ---- Serine/threonine-protein kinase WNK1 Source.293: DFBPPR8838 ---- Animal proteins ---- Cathepsin K Source.294: DFBPPR8971 ---- Animal proteins ---- Fibrillin-1 Source.295: DFBPPR8992 ---- Animal proteins ---- Hyaluronidase-3 Source.296: DFBPPR9096 ---- Animal proteins ---- Carboxypeptidase A1 Source.297: DFBPPR9102 ---- Animal proteins ---- Nuclear factor of activated T-cells, cytoplasmic 1 Source.298: DFBPPR9105 ---- Animal proteins ---- Lysine-specific demethylase 5C Source.299: DFBPPR9127 ---- Animal proteins ---- Transferrin receptor protein 1 Source.300: DFBPPR9242 ---- Animal proteins ---- Carboxypeptidase B Source.301: DFBPPR9283 ---- Animal proteins ---- Neuroendocrine convertase 2 Source.302: DFBPPR9314 ---- Animal proteins ---- Regucalcin Source.303: DFBPPR9339 ---- Animal proteins ---- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit Source.304: DFBPPR9387 ---- Animal proteins ---- Protein ATP1B4 Source.305: DFBPPR9427 ---- Animal proteins ---- Protein quaking Source.306: DFBPPR9451 ---- Animal proteins ---- M-phase inducer phosphatase 3 Source.307: DFBPPR9543 ---- Animal proteins ---- Beta-glucuronidase Source.308: DFBPPR9664 ---- Animal proteins ---- Perilipin-2 Source.309: DFBPPR9688 ---- Animal proteins ---- Outer dense fiber protein 1 Source.310: DFBPPR9784 ---- Animal proteins ---- Translocator protein Source.311: DFBPPR9838 ---- Animal proteins ---- Transcription factor PU.1 Source.312: DFBPPR9937 ---- Animal proteins ---- Suppressor of tumorigenicity 7 protein Source.313: DFBPPR9997 ---- Animal proteins ---- Aryl hydrocarbon receptor nuclear translocator-like protein 1 Source.314: DFBPPR10047 ---- Animal proteins ---- Ovocleidin-116 Source.315: DFBPPR10049 ---- Animal proteins ---- Transient receptor potential cation channel subfamily V member 4 Source.316: DFBPPR10119 ---- Animal proteins ---- Down syndrome cell adhesion molecule homolog Source.317: DFBPPR10150 ---- Animal proteins ---- Tenascin Source.318: DFBPPR10355 ---- Animal proteins ---- Down syndrome cell adhesion molecule-like protein 1 homolog Source.319: DFBPPR10358 ---- Animal proteins ---- Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase Source.320: DFBPPR10367 ---- Animal proteins ---- RNA-binding protein 24 Source.321: DFBPPR10458 ---- Animal proteins ---- Neurofascin Source.322: DFBPPR10472 ---- Animal proteins ---- Cytosolic 5'-nucleotidase 3A Source.323: DFBPPR10579 ---- Animal proteins ---- Lysine-specific demethylase 5B Source.324: DFBPPR10612 ---- Animal proteins ---- Carboxypeptidase Z Source.325: DFBPPR10634 ---- Animal proteins ---- Procathepsin L Source.326: DFBPPR10671 ---- Animal proteins ---- Cilia- and flagella-associated protein 65 Source.327: DFBPPR10687 ---- Animal proteins ---- Transcriptional activator Myb Source.328: DFBPPR10703 ---- Animal proteins ---- Tensin Source.329: DFBPPR10706 ---- Animal proteins ---- BRISC and BRCA1-A complex member 2 Source.330: DFBPPR10712 ---- Animal proteins ---- Deoxyribonuclease-1 Source.331: DFBPPR10748 ---- Animal proteins ---- Sodium-coupled neutral amino acid transporter 2 Source.332: DFBPPR10752 ---- Animal proteins ---- Protein ATP1B4 Source.333: DFBPPR10833 ---- Animal proteins ---- Putative helicase MOV-10 Source.334: DFBPPR10848 ---- Animal proteins ---- Melatonin receptor type 1A Source.335: DFBPPR10897 ---- Animal proteins ---- Doublesex- and mab-3-related transcription factor 1 Source.336: DFBPPR10947 ---- Animal proteins ---- Cytosolic carboxypeptidase 1 Source.337: DFBPPR10982 ---- Animal proteins ---- Melatonin receptor type 1C Source.338: DFBPPR11010 ---- Animal proteins ---- Alpha-actinin-4 Source.339: DFBPPR11037 ---- Animal proteins ---- Disheveled-associated activator of morphogenesis 2 Source.340: DFBPPR11041 ---- Animal proteins ---- Chromodomain-helicase-DNA-binding protein 7 Source.341: DFBPPR11071 ---- Animal proteins ---- Pituitary homeobox 1 Source.342: DFBPPR11078 ---- Animal proteins ---- Sodium/potassium-transporting ATPase subunit beta-1 Source.343: DFBPPR11084 ---- Animal proteins ---- Magnesium transporter protein 1 Source.344: DFBPPR11112 ---- Animal proteins ---- Protein quaking Source.345: DFBPPR11272 ---- Animal proteins ---- Iroquois-class homeodomain protein IRX-4 Source.346: DFBPPR11363 ---- Animal proteins ---- Forkhead box protein D3 Source.347: DFBPPR11481 ---- Animal proteins ---- Homeobox protein HMX3 Source.348: DFBPPR11534 ---- Animal proteins ---- Coiled-coil domain-containing protein 80 Source.349: DFBPPR11551 ---- Animal proteins ---- Isoleucine--tRNA ligase, mitochondrial Source.350: DFBPPR11601 ---- Animal proteins ---- TBC domain-containing protein kinase-like protein Source.351: DFBPPR11603 ---- Animal proteins ---- Syntaxin-binding protein 1 Source.352: DFBPPR11612 ---- Animal proteins ---- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit Source.353: DFBPPR11660 ---- Animal proteins ---- Cathepsin K Source.354: DFBPPR11749 ---- Animal proteins ---- Homeobox protein Hox-A3 Source.355: DFBPPR11757 ---- Animal proteins ---- RNA-binding protein 38 Source.356: DFBPPR11829 ---- Animal proteins ---- Melatonin receptor type 1B Source.357: DFBPPR11867 ---- Animal proteins ---- Protein MIS12 homolog Source.358: DFBPPR11904 ---- Animal proteins ---- Paired box protein Pax-1 Source.359: DFBPPR11920 ---- Animal proteins ---- Transcription initiation factor TFIID subunit 2 Source.360: DFBPPR11947 ---- Animal proteins ---- Transcription factor SOX-8 Source.361: DFBPPR11968 ---- Animal proteins ---- AT-rich interactive domain-containing protein 5B Source.362: DFBPPR12028 ---- Animal proteins ---- Endoplasmic reticulum resident protein 29 Source.363: DFBPPR12032 ---- Animal proteins ---- Pleckstrin homology domain-containing family B member 2 Source.364: DFBPPR12044 ---- Animal proteins ---- 39S ribosomal protein L37, mitochondrial Source.365: DFBPPR12128 ---- Animal proteins ---- Suppressor of tumorigenicity 7 protein-like Source.366: DFBPPR12218 ---- Animal proteins ---- Suppressor of tumorigenicity 7 protein homolog Source.367: DFBPPR12343 ---- Animal proteins ---- Protein SLFN14 Source.368: DFBPPR12380 ---- Animal proteins ---- N-acylethanolamine-hydrolyzing acid amidase Source.369: DFBPPR12507 ---- Animal proteins ---- Cathepsin K Source.370: DFBPPR12562 ---- Animal proteins ---- Sodium/potassium-transporting ATPase subunit beta-1 Source.371: DFBPPR12595 ---- Animal proteins ---- Hyaluronidase PH-20 Source.372: DFBPPR12597 ---- Animal proteins ---- b(0,+)-type amino acid transporter 1 Source.373: DFBPPR12968 ---- Animal proteins ---- Phosphatidylinositol transfer protein alpha isoform Source.374: DFBPPR13085 ---- Animal proteins ---- Protein AAR2 homolog Source.375: DFBPPR13115 ---- Animal proteins ---- Suppressor of tumorigenicity 7 protein Source.376: DFBPPR13151 ---- Animal proteins ---- Transferrin receptor protein 1 Source.377: DFBPPR13165 ---- Animal proteins ---- Aryl hydrocarbon receptor nuclear translocator-like protein 1 Source.378: DFBPPR13214 ---- Animal proteins ---- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase Source.379: DFBPPR13276 ---- Animal proteins ---- Protein quaking Source.380: DFBPPR13287 ---- Animal proteins ---- 1,4-alpha-glucan-branching enzyme Source.381: DFBPPR13317 ---- Animal proteins ---- Myosin-2 Source.382: DFBPPR13419 ---- Animal proteins ---- Suppressor of tumorigenicity 7 protein Source.383: DFBPPR13549 ---- Animal proteins ---- Sodium/potassium-transporting ATPase subunit beta-1 Source.384: DFBPPR13641 ---- Animal proteins ---- Interferon alpha/beta receptor 1 Source.385: DFBPPR13646 ---- Animal proteins ---- Procathepsin L Source.386: DFBPPR13826 ---- Animal proteins ---- Translocator protein Source.387: DFBPPR13829 ---- Animal proteins ---- Melatonin receptor type 1A Source.388: DFBPPR13905 ---- Animal proteins ---- Melatonin-related receptor Source.389: DFBPPR13969 ---- Animal proteins ---- Suppressor of tumorigenicity 7 protein Source.390: DFBPPR14258 ---- Marine protein ---- Pituitary-specific positive transcription factor 1 Source.391: DFBPPR14293 ---- Marine protein ---- Photosystem II CP43 reaction center protein Source.392: DFBPPR14331 ---- Marine protein ---- Photosystem I P700 chlorophyll a apoprotein A1 Source.393: DFBPPR14351 ---- Marine protein ---- Photosystem II CP43 reaction center protein Source.394: DFBPPR14492 ---- Marine protein ---- Uncharacterized AAA domain-containing protein ycf46 Source.395: DFBPPR14553 ---- Marine protein ---- Glucocorticoid receptor Source.396: DFBPPR14587 ---- Marine protein ---- Thyrotropin subunit beta Source.397: DFBPPR14813 ---- Marine protein ---- Digestive cysteine proteinase 1 Source.398: DFBPPR14816 ---- Marine protein ---- Digestive cysteine proteinase 3 Source.399: DFBPPR14819 ---- Marine protein ---- Digestive cysteine proteinase 2 Source.400: DFBPPR14863 ---- Marine protein ---- Sodium/potassium-transporting ATPase subunit beta-233 Source.401: DFBPPR14868 ---- Marine protein ---- Sodium/potassium-transporting ATPase subunit beta-1 Source.402: DFBPPR14892 ---- Microorganism protein ---- Histone-lysine N-methyltransferase, H3 lysine-4 specific Source.403: DFBPPR14928 ---- Microorganism protein ---- Adenylosuccinate synthetase Source.404: DFBPPR14997 ---- Microorganism protein ---- High osmolarity signaling protein SHO1 Source.405: DFBPPR15024 ---- Microorganism protein ---- Leucine aminopeptidase 2 Source.406: DFBPPR15052 ---- Microorganism protein ---- 5'-3' exoribonuclease 2 Source.407: DFBPPR15201 ---- Microorganism protein ---- Acetyl-CoA hydrolase Source.408: DFBPPR15205 ---- Microorganism protein ---- Glucose-6-phosphate 1-dehydrogenase Source.409: DFBPPR15231 ---- Microorganism protein ---- Protein SSH4 Source.410: DFBPPR15254 ---- Microorganism protein ---- D-arabinono-1,4-lactone oxidase Source.411: DFBPPR15270 ---- Microorganism protein ---- Protein SQS1 Source.412: DFBPPR15311 ---- Microorganism protein ---- Chitin synthase export chaperone Source.413: DFBPPR15312 ---- Microorganism protein ---- Chitin synthase export chaperone Source.414: DFBPPR15380 ---- Microorganism protein ---- Probable kinetochore protein NDC80 Source.415: DFBPPR15519 ---- Microorganism protein ---- Mitochondrial genome maintenance protein MGM101 Source.416: DFBPPR15529 ---- Microorganism protein ---- Oleate activated transcription factor 3 Source.417: DFBPPR15645 ---- Microorganism protein ---- Putative transferase CAF17, mitochondrial Source.418: DFBPPR15820 ---- Microorganism protein ---- 6-phospho-beta-galactosidase Source.419: DFBPPR15879 ---- Microorganism protein ---- Probable DNA polymerase Source.420: DFBPPR7772 ---- Plant protein ---- Photosystem I P700 chlorophyll a apoprotein A1 Source.421: DFBPPR7795 ---- Plant protein ---- NAD(P)H-quinone oxidoreductase subunit I, chloroplastic Source.422: DFBPPR7935 ---- Plant protein ---- Cytochrome b Source.423: DFBPPR7992 ---- Plant protein ---- Photosystem I P700 chlorophyll a apoprotein A1 Source.424: DFBPPR8029 ---- Plant protein ---- Vignain Source.425: DFBPPR8034 ---- Plant protein ---- Linoleate 9S-lipoxygenase 1 Source.426: DFBPPR8039 ---- Plant protein ---- Linoleate 9S-lipoxygenase Source.427: DFBPPR8044 ---- Plant protein ---- Photosystem I P700 chlorophyll a apoprotein A1 Source.428: DFBPPR8066 ---- Plant protein ---- NAD(P)H-quinone oxidoreductase subunit I, chloroplastic Source.429: DFBPPR8070 ---- Plant protein ---- Glucan endo-1,3-beta-glucosidase, basic isoform Source.430: DFBPPR8224 ---- Plant protein ---- Photosystem I P700 chlorophyll a apoprotein A1 Source.431: DFBPPR8236 ---- Plant protein ---- NAD(P)H-quinone oxidoreductase subunit I, chloroplastic Source.432: DFBPPR8250 ---- Plant protein ---- NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic Source.433: DFBPPR8256 ---- Plant protein ---- S-adenosylmethionine decarboxylase proenzyme
Link-research Inductive analysis	There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

α-Glucosidase inhibitory activity

Inhibitor of α-Glucosidase (AGH, EC 3.2.1.20). Tyr-Tyr-Pro-Leu which showed a potent inhibition against yeast AGH was selected as a skeleton peptide. As summarized five peptides were synthesized , and the AGH inhibition was determined. Substitution of Leu by Gly at the C-terminus of Tyr-Pro-Leu exhibited a similar AGH inhibition (IC₅₀ = 5.0 mM ), whereas a 6-fold reduction of in hibition activity was observed with Tyr-Pro-Tyr (IC₅₀ = 25.8 mM ). These results indicate that aliphatic amino acids, e.g. Leu or Gly at the C-terminus of the tri-peptide was more favorable than aromatic ones to inhibit AGH.

Table 1 AGH inhibitory activity of synthetic analogues of the peptide isolated from muscle hydrolyzate ^a
Sequence	IC50 (mM)
Tyr-Tyr-Pro-Leu	3.7 ± 0.02
Tyr-Pro-Leu	3.9 ± 0.02
Pro-Leu	No inhibition
Tyr-Pro	16.8 ± 0.08
Tyr-Pro-Gly	5.0 ± 0.01
Tyr-Pro-Tyr	25.8 ± 0.12

^a The analogue peptides were synthesized on the basis of the sequence of Tyr-Tyr-Pro-Leu isolated from the hydrolyzate.

Specific target protein(s)

Specific Target Protein(s):
Lysosomal alpha-glucosidase

Taste properties & Structure

Bitterness

Literature report	N.D
Bitter prediction tools	Bitter taste ^prediction

SMILES

N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O

Preparation method

Mode of preparation	Synthesis peptide
Enzyme(s)/starter culture	The peptide was synthesized using Fmoc solid phase synthesis on a Kokusan Peptide Synthesizer.

Stability & Cytotoxicity

Peptide stability

Literature report:	N.D
EHP-Tool:	Enzymatic Hydrolysis Prediction Tool (EHP-Tool)

Peptide cytotoxicity

Literature report:	N.D
Prediction:	ToxinPred

Additional information

(1) AGH inhibitory studies of Try-Tyr-Pro-Leu and its derivatives demonstrated the importance of the tri-peptide chain length as well as the hydrophobic aromatic amino acid tyrosine at the N-terminus, aliphatic amino acids at the C-terminus, as well as an amide proton from the peptide chain at the middle position of the tri-peptide to develop AGH inhibition activity.
(2) Although the sequenc (Tyr-Pro-Tyr) is only an synthetic analogue of the peptide and is not found in the sardine muscle hydrolyzate, it is likely to be present in the sardine muscle, or other foods, for later research and discovery, we add this peptde to the DFBP database.

Database cross-references

DFBP

[D1]	DFBPDPIV0042
[D2]	DFBPOPIO0134, DFBPOPIO0135
[D3]	DFBPMUFU0726

[D4]

[D5]

[D6]

[D7]

Reference(s)

Primary literature	Matsui T, Oki T, Osajima Y. Isolation and identification of peptidic alpha-glucosidase inhibitors derived from sardine muscle hydrolyzate. Z Naturforsch C J Biosci. 1999 Mar-Apr;54(3-4):259-63. PMID: 10408829 DOI: 10.1515/znc-1999-3-417
Other literature(s)	[1] Matsui T, Yoshimoto C, Osajima K, et al. In vitro survey of alpha-glucosidase inhibitory food components.[J]. Journal of the Agricultural Chemical Society of Japan, 1996, 60(12):2019-2022.
PubDate	1999